Aflatoxin B1 Antibody (6A10): sc-66016

Aflatoxin B1 Antibody (6A10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Aflatoxin B1 protein of mouse, rat, and human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Aflatoxin B1 (6A10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aflatoxin B1 is a potent mycotoxin produced primarily by the molds Aspergillus flavus and Aspergillus parasiticus, which thrive in warm, humid environments, particularly affecting crops like corn and peanuts. Aflatoxin B1′s significance lies in causing severe health issues, including liver cancer, making detection crucial in food safety and public health. Aflatoxin B1′s structure contains a highly reactive epoxide group that interacts with cellular macromolecules, leading to mutagenic effects. Understanding Aflatoxin B1′s structural characteristics can aid in developing strategies to mitigate toxic effects and improve detection methods in agricultural products. Aspergillus flavus presence in crops serves as a critical indicator for potential Aflatoxin contamination, emphasizing the need for effective monitoring and control measures in food production.

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Aflatoxin B1 Antibody (6A10) References:

1. Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B(1).  |  Montero, R., et al. 2003. Mutagenesis. 18: 211-6. PMID: 12621079
2. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin.  |  Egner, PA., et al. 2003. Mutat Res. 523-524: 209-16. PMID: 12628519
3. Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks.  |  Tedesco, D., et al. 2004. Poult Sci. 83: 1839-43. PMID: 15554059
4. Lack of the effect of mycotoxins-aflatoxin B1 and ochratoxin A on some functions of rat adipocytes.  |  Szkudelska, K., et al. 2005. Toxicol In Vitro. 19: 771-7. PMID: 15963681
5. Chemoprevention by thyme oils of Aspergillus parasiticus growth and aflatoxin production.  |  Rasooli, I. and Owlia, P. 2005. Phytochemistry. 66: 2851-6. PMID: 16289146
6. A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.  |  Bradshaw, RE., et al. 2006. Mycopathologia. 161: 283-94. PMID: 16649078
7. The effect of storage time and agroecological zone on mould incidence and aflatoxin contamination of maize from traders in Uganda.  |  Kaaya, AN. and Kyamuhangire, W. 2006. Int J Food Microbiol. 110: 217-23. PMID: 16822572
8. A cross sectional study of hepatitis B, C, some trace elements, heavy metals, aflatoxin B1 and schistosomiasis in a rural population, Egypt.  |  Sayed, HA., et al. 2005. J Egypt Public Health Assoc. 80: 355-88. PMID: 16900614
9. Study of aflatoxin B1 and ochratoxin A production by natural microflora and Aspergillus parasiticus in black and green olives of Greek origin.  |  Ghitakou, S., et al. 2006. Food Microbiol. 23: 612-21. PMID: 16943059
10. Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice.  |  Hwang, SK., et al. 2009. Am J Respir Crit Care Med. 179: 1131-40. PMID: 19286625
11. Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.  |  Piao, L., et al. 2009. BMC Cell Biol. 10: 53. PMID: 19604401
12. Bioconversion of Waste Fiber Sludge to Bacterial Nanocellulose and Use for Reinforcement of CTMP Paper Sheets.  |  Chen, G., et al. 2017. Polymers (Basel). 9: PMID: 30965761

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aflatoxin B1 Antibody (6A10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Aflatoxin B1 Antibody (6A10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aflatoxin B1 Antibody (6A10) Specifications

Alternate Product Name: Aflatoxin B1

Product Clone Name: 6A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Aflatoxin B1

Epitope Species: Aflatoxin B1

Product Reactivity/Detection: Aflatoxin B1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Aflatoxin B1 Antibody (6A10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin