ADM Antibody (HTA91a/G2): sc-53154

ADM Antibody (HTA91a/G2) is a mouse monoclonal IgM antibody that detects adrenomedullin (ADM) in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ADM is a crucial vasodilator produced by various contractile cells, playing a significant role in regulating fluid and electrolyte balance as well as maintaining cardiovascular health. ADM (HTA91a/G2) antibody targets a protein involved in blood pressure modulation, with ADM levels often elevated in hypertensive patients, indicating importance in cardiovascular pathophysiology. ADM is primarily located in the vascular endothelium and adrenal medulla, where secretion into the bloodstream allows systemic effects. This localization enables ADM to act quickly on target tissues, influencing renal function and promoting natriuresis, which is the excretion of sodium in urine. ADM′s ability to increase glomerular filtration rate while decreasing sodium reabsorption in the distal tubules underscores importance in fluid homeostasis and blood pressure regulation. Furthermore, ADM′s presence in the central nervous system allows modulation of appetite and energy balance, highlighting multifaceted roles in both cardiovascular and metabolic processes. With diverse functions and critical involvement in various physiological pathways, anti-ADM antibody (HTA91a/G2) serves as an essential tool for researchers studying cardiovascular health and related disorders.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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ADM Antibody (HTA91a/G2) References:

1. The peroxidase activity of ADM-Fe(3+) cooperates with lipid peroxidation: The participation of hydroperoxide and hydroxyl radicals in the damage to proteins and DNA.  |  Miura, T. 2015. Chem Biol Interact. 236: 67-73. PMID: 25920575
2. Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells.  |  Liu, W., et al. 2016. Am J Cancer Res. 6: 2547-2560. PMID: 27904770
3. Impact of Acellular Dermal Matrix (ADM) Use Under Mastectomy Flap Necrosis on Perioperative Outcomes of Prosthetic Breast Reconstruction.  |  Kim, SY. and Bang, SI. 2017. Aesthetic Plast Surg. 41: 275-281. PMID: 28204936
4. PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer.  |  Chen, Y., et al. 2021. J Cell Mol Med. 25: 6948-6962. PMID: 34117724
5. miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis.  |  Ge, W., et al. 2022. Gastroenterology. 162: 269-284. PMID: 34547282
6. Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia.  |  da Silva, L., et al. 2022. Cell Death Discov. 8: 378. PMID: 36055991
7. O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance.  |  Liu, Y., et al. 2023. EMBO Rep. 24: e56458. PMID: 37249035
8. Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.  |  Parte, S., et al. 2024. Gastroenterology. 166: 842-858.e5. PMID: 38154529
9. Impact of the Peripheral Ligand Layer on the Excited-State Deactivation Mechanism of Au38S2(S-Adm)20 and Au30(S-Adm)18 (S-Adm = Adamantanethiolate) Clusters.  |  Li, K., et al. 2024. J Phys Chem Lett. 15: 9216-9225. PMID: 39225489
10. An adrenomedullin (ADM) fragment retains the systemic vasodilator activity of human ADM.  |  Hao, Q., et al. 1994. Life Sci. 54: PL265-70. PMID: 8152335