Adenosine A1-R Antibody (HA1): sc-66193

Adenosine A1-R Antibody (HA1) is a mouse monoclonal IgM antibody that detects Adenosine A1-R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Adenosine A1-R antibody (HA1) is available as a non-conjugated format. Adenosine A1 receptor plays a crucial role in various physiological processes, including cardiac function regulation and neurotransmission. Located primarily in the central nervous system and heart, Adenosine A1-R (HA1) monoclonal antibody helps study A1 receptor′s role in mediating adenosine effects, which include cardioprotection during ischemic events and neurotransmitter release modulation. A1 receptor activation leads to decreased heart rate and myocardial oxygen consumption, making A1 receptor vital for maintaining cardiac homeostasis. A1 receptor interaction with G proteins initiates intracellular signaling pathways that influence cell survival and apoptosis, highlighting A1 receptor importance in health and disease. Anti-Adenosine A1-R antibody (HA1) serves as a valuable tool for investigating adenosine signaling roles in various biological contexts.

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Adenosine A1-R Antibody (HA1) References:

1. Molecular cloning and expression of an adenosine A2b receptor from human brain.  |  Pierce, KD., et al. 1992. Biochem Biophys Res Commun. 187: 86-93. PMID: 1325798
2. Molecular characterization of a human brain adenosine A2 receptor.  |  Furlong, TJ., et al. 1992. Brain Res Mol Brain Res. 15: 62-6. PMID: 1331670
3. Cloning and expression of an A1 adenosine receptor from rat brain.  |  Mahan, LC., et al. 1991. Mol Pharmacol. 40: 1-7. PMID: 1857334
4. Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay.  |  Saecker, L., et al. 2023. Front Pharmacol. 14: 1172551. PMID: 37324481
5. Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor.  |  Liu, H., et al. 2023. Front Physiol. 14: 1242975. PMID: 37700760
6. Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.  |  Zhu, W., et al. 2024. Cell Rep Med. 5: 101477. PMID: 38508143
7. Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.  |  Zhu, W., et al. 2024. Cell Rep Med. 5: 101563. PMID: 38718795
8. Molecular cloning and characterization of the human A3 adenosine receptor.  |  Salvatore, CA., et al. 1993. Proc Natl Acad Sci U S A. 90: 10365-9. PMID: 8234299
9. Activation of adenosine A3 receptors on macrophages inhibits tumor necrosis factor-alpha.  |  McWhinney, CD., et al. 1996. Eur J Pharmacol. 310: 209-16. PMID: 8884219
10. Adenosine inhibits growth of human aortic smooth muscle cells via A2B receptors.  |  Dubey, RK., et al. 1998. Hypertension. 31: 516-21. PMID: 9453355
11. The A2A adenosine receptor mediates coronary vasodilation.  |  Belardinelli, L., et al. 1998. J Pharmacol Exp Ther. 284: 1066-73. PMID: 9495868
12. Ca2+ dependence of the response of three adenosine type receptors in rat hepatocytes.  |  Guinzberg, R., et al. 1997. Eur J Pharmacol. 340: 243-7. PMID: 9580059

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenosine A1-R Antibody (HA1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenosine A1-R Antibody (HA1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenosine A1-R Antibody (HA1) Specifications

Alternate Product Name: ADORA1

Product Clone Name: HA1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Adenosine A1-R

Epitope Species:

Product Reactivity/Detection: Adenosine A1-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Adenosine A1-R Antibody (HA1): N/A

The preferred Adenosine A1-R antibody is Adenosine A1-R Antibody (D-5): sc-514337.