ADAMTS-1 Antibody (3E4C6B4): sc-47726
- ADAMTS-1 Antibody (3E4C6B4) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against purified recombinant ADAMTS-1 of human origin
- recommended for detection of precursor and mature ADAMTS-1 of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ADAMTS-1 Antibody (3E4C6B4) for WB applications. These reagents are now offered in bundles with ADAMTS-1 Antibody (3E4C6B4) (see ordering information below).
ADAMTS-1 Antibody (3E4C6B4) is a mouse monoclonal IgG1 antibody that detects ADAMTS-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). ADAMTS-1, also known as METH-1, C3-C5, and KIAA1346, belongs to a novel family of proteins characterized by metalloprotease, disintegrin, and Thrombospondin domains, which play crucial roles in various biological processes. ADAMTS-1 is primarily secreted and undergoes proteolytic processing, exhibiting significant homology with ADAMTS-2, yet displaying distinct expression patterns across different tissues and cell lines. ADAMTS-1 has shown greater anti-angiogenic activity than Thrombospondin-1 or endostatin, making ADAMTS-1 a potential therapeutic target for inhibiting new blood vessel formation in various tumor types. A spacer region and Thrombospondin type I motifs at the carboxy-terminus are essential for anchoring ADAMTS-1 to the extracellular matrix, facilitating functional roles in modulating tumor microenvironment and influencing cellular interactions. Anti-ADAMTS-1 antibody (3E4C6B4) serves as a valuable tool for researchers investigating angiogenesis mechanisms and therapeutic potential in cancer and other diseases.
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ADAMTS-1 Antibody (3E4C6B4) References:
- ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections. | Ren, P., et al. 2013. Ann Thorac Surg. 95: 570-7. PMID: 23245439
- ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells. | Silva, SV., et al. 2016. PLoS One. 11: e0165061. PMID: 27764205
- ADAMTS-1 in abdominal aortic aneurysm. | Vorkapic, E., et al. 2017. PLoS One. 12: e0178729. PMID: 28570682
- ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. | Noriega-Guerra, H., et al. 2018. Exp Cell Res. 363: 271-282. PMID: 29355494
- ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis. | Lambert, J., et al. 2020. J Cell Sci. 133: PMID: 32269093
- Role of Adamts-1 in Pleomorphic Xanthoastrocytoma Tumor Cells Progression. | Gokce, A., et al. 2021. Turk Neurosurg. 31: 731-739. PMID: 34169995
- ADAMTS-1 inhibits angiogenesis via the PI3K/Akt-eNOS-VEGF pathway in lung cancer cells. | Wang, B., et al. 2019. Transl Cancer Res. 8: 2725-2735. PMID: 35117030
- Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis. | Tayman, MA. and Koyuncu, İ. 2023. Biotech Histochem. 98: 126-131. PMID: 36093887
- Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma. | de Souza Neto, OR., et al. 2022. Int J Dent. 2022: 5235376. PMID: 36338393
- ADAMTS-1 has nuclear localization in cells with epithelial origin and leads to decreased cell migration. | Silva, SV., et al. 2023. Exp Cell Res. 433: 113852. PMID: 37951335
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAMTS-1 Antibody (3E4C6B4) | sc-47726 | 200 µg/ml | $316.00 | |||
ADAMTS-1 Antibody (3E4C6B4): m-IgG Fc BP-HRP Bundle | sc-538936 | 200 µg Ab; 10 µg BP | $354.00 | |||
ADAMTS-1 Antibody (3E4C6B4): m-IgG1 BP-HRP Bundle | sc-541165 | 200 µg Ab; 20 µg BP | $354.00 |