ADAMTS-1 Antibody (3C8F4): sc-47727
- ADAMTS-1 Antibody (3C8F4) is a mouse monoclonal IgG1 κ ADAMTS-1 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against purified recombinant ADAMTS-1 of human origin
- ADAMTS-1 Antibody (3C8F4) is recommended for detection of precursor and mature ADAMTS-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-ADAMTS-1 Antibody (3C8F4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ADAMTS-1 Antibody (3C8F4) for WB and IHC(P) applications. These reagents are now offered in bundles with ADAMTS-1 Antibody (3C8F4) (see ordering information below).
ADAMTS-1 Antibody (3C8F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ADAMTS-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-ADAMTS-1 antibody (3C8F4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ADAMTS-1, also known as METH-1, C3-C5, and KIAA1346, plays a crucial role in regulating extracellular matrix components and is involved in processes such as angiogenesis and tissue remodeling. ADAMTS-1 is secreted and undergoes proteolytic processing, which is essential for modulating the activity of other proteins within the extracellular matrix. ADAMTS-1′s structure includes metalloprotease, disintegrin, and thrombospondin domains, which are vital for interactions with various substrates and other proteins. These domains allow ADAMTS-1 to effectively inhibit angiogenesis, making ADAMTS-1 a potential therapeutic target in cancer treatment, where new blood vessel formation is critical for tumor growth and metastasis. The spacer region and thrombospondin type I motifs at ADAMTS-1′s carboxy-terminus are important for anchoring to the extracellular matrix, influencing biological activity and interactions with other matrix components.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ADAMTS-1 Antibody (3C8F4) References:
- ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix. | Kuno, K., et al. 1999. J Biol Chem. 274: 18821-6. PMID: 10373500
- METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. | Vázquez, F., et al. 1999. J Biol Chem. 274: 23349-57. PMID: 10438512
- Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity. | de Assis Lima, M., et al. 2021. Cell Signal. 77: 109827. PMID: 33161094
- Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis. | Buran, T., et al. 2023. BMC Gastroenterol. 23: 345. PMID: 37798683
- Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. | Kuno, K., et al. 1997. J Biol Chem. 272: 556-62. PMID: 8995297
- The exon/intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an ADAM family protein with TSP motifs. | Kuno, K., et al. 1997. Genomics. 46: 466-71. PMID: 9441751
- ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. | Kuno, K. and Matsushima, K. 1998. J Biol Chem. 273: 13912-7. PMID: 9593739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAMTS-1 Antibody (3C8F4) | sc-47727 | 200 µg/ml | $316.00 | |||
ADAMTS-1 Antibody (3C8F4): m-IgG Fc BP-HRP Bundle | sc-526735 | 200 µg Ab; 10 µg BP | $354.00 | |||
ADAMTS-1 Antibody (3C8F4): m-IgG1 BP-HRP Bundle | sc-532108 | 200 µg Ab; 20 µg BP | $354.00 | |||
ADAMTS-1 Antibody (3C8F4) AC | sc-47727 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ADAMTS-1 Antibody (3C8F4) HRP | sc-47727 HRP | 200 µg/ml | $316.00 | |||
ADAMTS-1 Antibody (3C8F4) FITC | sc-47727 FITC | 200 µg/ml | $330.00 | |||
ADAMTS-1 Antibody (3C8F4) PE | sc-47727 PE | 200 µg/ml | $343.00 | |||
ADAMTS-1 Antibody (3C8F4) Alexa Fluor® 488 | sc-47727 AF488 | 200 µg/ml | $357.00 | |||
ADAMTS-1 Antibody (3C8F4) Alexa Fluor® 546 | sc-47727 AF546 | 200 µg/ml | $357.00 | |||
ADAMTS-1 Antibody (3C8F4) Alexa Fluor® 594 | sc-47727 AF594 | 200 µg/ml | $357.00 | |||
ADAMTS-1 Antibody (3C8F4) Alexa Fluor® 647 | sc-47727 AF647 | 200 µg/ml | $357.00 | |||
ADAMTS-1 Antibody (3C8F4) Alexa Fluor® 680 | sc-47727 AF680 | 200 µg/ml | $357.00 | |||
ADAMTS-1 Antibody (3C8F4) Alexa Fluor® 790 | sc-47727 AF790 | 200 µg/ml | $357.00 |