Molecular structure of ACY-1215, CAS Number: 1316214-52-4
ACY-1215 (CAS 1316214-52-4)
Alternate Names:
2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; Ricolinostat
CAS Number:
1316214-52-4
Molecular Weight:
433.5
Molecular Formula:
C24H27N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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ACY-1215 (CAS 1316214-52-4) References
- HDAC6-specific inhibitor alleviates hashimoto's thyroiditis through inhibition of Th17 cell differentiation. | Chang, Q., et al. 2022. Mol Immunol. 149: 39-47. PMID: 35717700
- First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation. | Yue, K., et al. 2022. J Med Chem. 65: 12140-12162. PMID: 36073117
- HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling. | Vong, P., et al. 2023. J Cell Mol Med. 27: 174-188. PMID: 36578217
- Corrigendum: Role of selective histone deacetylase 6 inhibitor ACY-1215 in cancer and other human diseases. | Li, J., et al. 2022. Front Pharmacol. 13: 1117936. PMID: 36588693
- Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC. | Zhang, H., et al. 2023. J Thorac Oncol. 18: 882-895. PMID: 36958689
- Alleviation of neurotoxicity induced by polystyrene nanoplastics by increased exocytosis from neurons. | Han, SW., et al. 2023. Biochem Biophys Res Commun. 668: 19-26. PMID: 37235915
- Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation. | Sun, K., et al. 2023. Mol Pain. 19: 17448069231218352. PMID: 37982151
- HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy. | Wen, Y., et al. 2024. Cancer Immunol Immunother. 73: 7. PMID: 38231305
- Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice. | Lin, QC., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167137. PMID: 38527593
- Downregulation of HDAC6 mitigates lung ischemia/reperfusion injury depending on activation of Nrf2/HO-1 signaling pathway and inactivation of ERK/NF-κB signaling pathway. | Zhou, H., et al. 2024. Tissue Cell. 89: 102446. PMID: 38936199
Inhibitor of:
ANKRD20A5, HDAC6, HEF1, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3F, Histone H2A, Histone H2B, MCT12, pan-Acetyl, Smarcad1, TAF6L, and ZMAT4.Activator of:
EG384244, EG546205, GBGT1, Mot1, and SMYD3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACY-1215, 25 mg | sc-507455 | 25 mg | $110.00 |