Actin Antibody (8.S2.1): sc-70319
- Actin Antibody (8.S2.1) is a mouse monoclonal IgM κ, cited in 53 publications, provided at 200 µg/ml
- raised against monocytes and U-937 histolytic lymphoma of human origin
- recommended for detection of Actin of mouse, rat, human and rabbit origin by WB, IP, IF, IHC(P) and FCM; non cross-reactive with the N-terminal 40 amino acids
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See beta Actin (C4): sc-47778 for Actin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Actin Antibody (8.S2.1). This work is in progress.
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SEE ALSO...
Actin Antibody (8.S2.1) is a mouse monoclonal IgM kappa light chain antibody raised against monocytes and U-937 histolytic lymphoma of human origin, demonstrating reactivity with mouse, rat, human, and rabbit species. Actin plays a critical role in forming microfilaments within the cytoskeleton, existing in both globular (G-actin) and filamentous (F-actin) forms, which are essential for various cellular processes such as muscle contraction, cell motility, and maintenance of cell shape and integrity. Actin filaments can form both stable structures, like those in muscle sarcomeres, and dynamic structures, such as the leading edge of motile cells. While primarily localized in the cytoplasm, actin is also present in the nucleus, contributing to chromatin remodeling and gene transcription. The dynamics of actin are regulated by small GTPases like Rho, Rac, and Cdc42: Rho regulates the formation of stress fibers and focal adhesions; Rac controls actin accumulation at the plasma membrane leading to lamellipodia formation; and Cdc42 stimulates the formation of filopodia. Actin interacts with numerous proteins, including myosin for muscle contraction, tropomyosin and troponin for muscle regulation, and proteins like profilin and cofilin that regulate actin polymerization and depolymerization. These interactions are crucial for cell movement, division, and intracellular transport, underscoring the importance of actin in maintaining cellular function and structure. Anti-actin antibody (8.S2.1) is a valuable tool for researchers studying actin dynamics and related protein-protein interactions across various species.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Actin Antibody (8.S2.1) | sc-70319 | 200 µg/ml | $322.00 | |||
Actin Antibody (8.S2.1) FITC | sc-70319 FITC | 200 µg/ml | $336.00 | |||
Actin Antibody (8.S2.1) PE | sc-70319 PE | 200 µg/ml | $349.00 |