ACSL5 Antibody (A-2): sc-365478

ACSL5 Antibody (A-2) is a mouse monoclonal IgM antibody that detects ACSL5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ACSL5 antibody (A-2) is available as the non-conjugated format. ACSL5, a member of the acyl-CoA synthetase family, plays a crucial role in lipid metabolism by catalyzing the conversion of long-chain fatty acids into acyl-CoA derivatives, which are essential for various metabolic pathways, including the synthesis of triacylglycerol and phospholipids, as well as β-oxidation for energy production. ACSL5 is predominantly localized in the mitochondria, microsomes, and peroxisomes, highlighting its importance in cellular energy homeostasis and lipid biosynthesis. ACSL5 exhibits a preference for C16-C18 unsaturated fatty acids and is highly expressed in tissues such as the uterus and spleen. ACSL5 expression levels are significant in the context of cancer, as a decrease in ACSL5 has been associated with tumorigenesis in various cancers, including endometrioid adenocarcinomas and colorectal carcinomas, making ACSL5 a valuable marker for differentiation in the gastrointestinal tract.

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ACSL5 Antibody (A-2) References:

1. Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase.  |  Muoio, DM., et al. 2000. Am J Physiol Endocrinol Metab. 279: E1366-73. PMID: 11093925
2. Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?  |  Coleman, RA., et al. 2002. J Nutr. 132: 2123-6. PMID: 12163649
3. Impaired expression of acyl-CoA-synthetase 5 in epithelial tumors of the small intestine.  |  Gassler, N., et al. 2003. Hum Pathol. 34: 1048-52. PMID: 14608540
4. Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5.  |  Gassler, N., et al. 2005. Histol Histopathol. 20: 409-14. PMID: 15736044
5. Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5.  |  Obermüller, N., et al. 2006. Int J Colorectal Dis. 21: 130-4. PMID: 15809837
6. Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas.  |  Gassler, N., et al. 2005. J Pathol. 207: 295-300. PMID: 16110457
7. Expression of acyl-CoA synthetase 5 in human endometrium and in endometrioid adenocarcinomas.  |  Gassler, N., et al. 2005. Histopathology. 47: 501-7. PMID: 16241998
8. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes.  |  Oikawa, E., et al. 1998. J Biochem. 124: 679-85. PMID: 9722683

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACSL5 Antibody (A-2) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ACSL5 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACSL5 Antibody (A-2) Specifications

Alternate Product Name: ACSL5

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 661-683

Epitope Target: ACSL5

Epitope Species: human

Product Reactivity/Detection: short isoform and long isoform of ACSL5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ACSL5 Antibody (A-2): P: Blocking Peptide