ACSL1 Antibody (3G4): sc-293281
- ACSL1 Antibody (3G4) is a mouse monoclonal IgG2a κ ACSL1 antibody provided at 100 µg/ml
- raised against amino acids 48-145 of ACSL1 of human origin
- recommended for detection of ACSL1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACSL1 Antibody (3G4). This work is in progress.
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ACSL1 Antibody (3G4) is a mouse monoclonal IgG2a kappa light chain antibody that detects ACSL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ACSL1 antibody (3G4) is available as a non-conjugated monoclonal isotype antibody. ACSL1 plays a crucial role in lipid metabolism, specifically in the activation of long-chain fatty acids to acyl-CoA derivatives, which are essential for various metabolic pathways, including the synthesis of cellular lipids and the β-oxidation process. This activation allows fatty acids to be utilized for energy production and the formation of important biomolecules such as triacylglycerols, phospholipids, and cholesteryl esters. ACSL1 is predominantly expressed in the liver and exhibits a preference for substrates like palmitoleate, oleate, and linoleate, highlighting its significance in maintaining lipid homeostasis and energy balance within the body. ACSL1′s ability to interact with various long-chain fatty acids underscores its importance in metabolic regulation and potential implications in metabolic disorders.
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ACSL1 Antibody (3G4) References:
- Thioesterification of 2-arylpropionic acids by recombinant acyl-coenzyme A synthetases (ACS1 and ACS2). | Sevoz, C., et al. 2000. Drug Metab Dispos. 28: 398-402. PMID: 10725307
- Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase. | Muoio, DM., et al. 2000. Am J Physiol Endocrinol Metab. 279: E1366-73. PMID: 11093925
- Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. | Lewin, TM., et al. 2001. J Biol Chem. 276: 24674-9. PMID: 11319232
- Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways? | Coleman, RA., et al. 2002. J Nutr. 132: 2123-6. PMID: 12163649
- Characterization of the Acyl-CoA synthetase activity of purified murine fatty acid transport protein 1. | Hall, AM., et al. 2003. J Biol Chem. 278: 43008-13. PMID: 12937175
- TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. | Huh, JY., et al. 2020. Cell Metab. 32: 1012-1027.e7. PMID: 33152322
- Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. | Beatty, A., et al. 2021. Nat Commun. 12: 2244. PMID: 33854057
- ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability. | Zhang, Q., et al. 2023. Cell Death Discov. 9: 83. PMID: 36882396
- Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. | Wright, T., et al. 2024. Mol Cell. 84: 1338-1353.e8. PMID: 38503284
- The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy. | Hong, J., et al. 2024. Cell Death Differ. 31: 1561-1575. PMID: 39134684
- Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice. | Yang, M., et al. 2024. Nat Commun. 15: 7746. PMID: 39232011
- Biochemical studies of two rat acyl-CoA synthetases, ACS1 and ACS2. | Iijima, H., et al. 1996. Eur J Biochem. 242: 186-90. PMID: 8973631
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACSL1 Antibody (3G4) | sc-293281 | 100 µg/ml | $316.00 |