ACSL1 Activators
ACSL1, or Acyl-CoA Synthetase Long Chain Family Member 1, serves as a critical enzyme in the metabolism of long-chain fatty acids. It catalyzes the initial step in the intracellular metabolism of fatty acids by converting them into their active form, acyl-CoA. This reaction is fundamental for various cellular processes, including β-oxidation, phospholipid synthesis, and the production of lipid-derived signaling molecules. The activity of ACSL1 is essential for maintaining energy homeostasis, as it facilitates the utilization of fatty acids for energy production, particularly in tissues with high metabolic rates such as the liver, heart, and skeletal muscle. Beyond its role in energy metabolism, ACSL1 also contributes to lipid remodeling and the regulation of cellular lipid composition, impacting membrane fluidity, vesicle trafficking, and signal transduction processes. The enzyme's activity is tightly regulated by nutritional, hormonal, and intracellular signals to ensure a balanced lipid metabolism in response to changing physiological needs.
The activation of ACSL1 is mediated through a complex network of signaling pathways that respond to the cellular energy status and extracellular signals. Mechanisms of activation involve allosteric modulation by various metabolites, post-translational modifications, and interactions with proteins that influence its substrate specificity and catalytic activity. Given the enzyme's central role in lipid metabolism, its activation is closely linked to the regulation of peroxisome proliferator-activated receptors (PPARs), which are nuclear receptors that govern the expression of genes involved in fatty acid oxidation and lipid homeostasis. Activation of ACSL1 by small molecule compounds often occurs through the modulation of these receptors, highlighting the interconnected nature of metabolic regulation. Moreover, the enzyme's function and activation are influenced by the cellular lipid environment, which can alter the availability of substrates and cofactors necessary for its activity. This dynamic regulation ensures that ACSL1 activity is modulated in accordance with the cellular demand for fatty acid metabolism, underscoring its adaptability to various physiological states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
Oleoylethanolamide activates ACSL1 by binding to peroxisome proliferator-activated receptor alpha (PPAR-α), leading to an increase in ACSL1 activity as part of the fatty acid metabolism and signaling pathway. This activation enhances the enzyme's role in converting long-chain fatty acids into acyl-CoA derivatives, crucial for lipid biosynthesis and β-oxidation. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate indirectly activates ACSL1 by agonizing PPAR-α, which in turn upregulates the expression and activity of ACSL1 as part of its broad effects on lipid metabolism. This results in enhanced fatty acid utilization and improved lipid homeostasis, showcasing the drug's role in modulating lipid metabolic pathways involving ACSL1. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate activates ACSL1 by stimulating PPAR-α, a nuclear receptor that regulates lipid metabolism genes including ACSL1. This activation promotes the oxidation of fatty acids and the production of acyl-CoA, directly enhancing ACSL1's enzymatic function in lipid processing and energy homeostasis. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643 activates ACSL1 by selectively activating PPAR-α, leading to increased expression and activity of ACSL1 within the fatty acid β-oxidation pathway. This chemical's effect on PPAR-α demonstrates a direct pathway through which ACSL1 is activated, facilitating the metabolism of fatty acids into energy. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW7647 functions as a potent activator of ACSL1 by directly activating PPAR-α, which upregulates ACSL1 activity and enhances its role in lipid metabolism and fatty acid oxidation. This activation underscores the compound's efficacy in promoting lipid homeostasis through specific upregulation of ACSL1 function. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate indirectly activates ACSL1 by agonizing PPAR-α, thereby increasing ACSL1 activity as part of its mechanism of action in lipid lowering. This enhances fatty acid metabolism by promoting the conversion of fatty acids to their active form, acyl-CoA, thereby implicating ACSL1 in improved lipid processing. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil activates ACSL1 indirectly through PPAR-α activation, leading to enhanced fatty acid oxidation by upregulating ACSL1 activity. This demonstrates the drug's role in lipid regulation and its impact on ACSL1's enzymatic function in the metabolism of fatty acids. | ||||||
Ciprofibrate | 52214-84-3 | sc-204689 sc-204689A | 25 mg 100 mg | $58.00 $172.00 | ||
Ciprofibrate activates ACSL1 by engaging PPAR-α, leading to enhanced fatty acid metabolism through upregulation of ACSL1. This effect facilitates the enzyme's function in converting free fatty acids to acyl-CoA, highlighting its importance in lipid metabolic processes. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Although primarily known as a PPAR-γ agonist, Rosiglitazone can indirectly activate ACSL1 by cross-activation of PPAR-α, leading to increased ACSL1 activity in lipid metabolism and fatty acid oxidation. This illustrates the interconnectedness of metabolic pathways and the role of ACSL1 in these processes. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, while mainly acting on PPAR-γ, also has effects on PPAR-α, indirectly activating ACSL1 and promoting its role in fatty acid metabolism. This underscores the drug's utility in modulating lipid metabolism through ACSL1 activation. | ||||||