ACRV1 Antibody (A-9): sc-398536

ACRV1 Antibody (A-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects ACRV1 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACRV1 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACRV1, also known as acrosomal protein SP-10 or SPACA2, is a 265 amino acid protein encoded by a gene located on human chromosome 11q24.2, which is situated at the junction between 11q23 and 11q24. ACRV1 plays a significant role in sperm-zona binding and penetration, processes essential for successful fertilization. ACRV1 is expressed specifically in the testis and is associated with acrosomal membranes and the mature sperm matrix, originating from the acrosomal vesicle during spermatogenesis. ACRV1 has been identified as a potential immunogen for contraceptive vaccines, highlighting its importance in reproductive biology and potential applications in fertility control.

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ACRV1 Antibody (A-9) References:

1. Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10.  |  Reddi, PP., et al. 2002. J Reprod Immunol. 53: 25-36. PMID: 11730901
2. Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes.  |  Herr, JC., et al. 1992. Biol Reprod. 47: 11-20. PMID: 1637938
3. Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10.  |  Wright, RM., et al. 1990. Biol Reprod. 42: 693-701. PMID: 1693291
4. Assignment of the gene for human intra-acrosomal protein SP-10 to the p12----q13 region of chromosome 11.  |  Herr, JC., et al. 1991. J Androl. 12: 281-7. PMID: 1765564
5. Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10.  |  Homyk, M., et al. 1990. Fertil Steril. 53: 323-30. PMID: 2298314
6. Characterization of alternatively spliced human SP-10 mRNAs.  |  Freemerman, AJ., et al. 1995. Mol Reprod Dev. 41: 100-8. PMID: 7619499
7. Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction.  |  Foster, JA., et al. 1994. Biol Reprod. 51: 1222-31. PMID: 7888499
8. Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23-->q24 of chromosome 11 by nonisotopic in situ hybridization.  |  Golden, WL., et al. 1993. Genomics. 18: 446-9. PMID: 8288254
9. Cloning and characterization of the gene coding for the human acrosomal protein SP-10.  |  Wright, RM., et al. 1993. Biol Reprod. 49: 316-25. PMID: 8373955

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACRV1 Antibody (A-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-ACRV1 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACRV1 Antibody (A-9) Specifications

Alternate Product Name: ACRV1

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 138-261

Epitope Target: ACRV1

Epitope Species: mouse

Product Reactivity/Detection: ACRV1

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for ACRV1 Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin