acrogranin Antibody (2A3C5): sc-81151
- acrogranin Antibody (2A3C5) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 434-573 of acrogranin of human origin
- recommended for detection of acrogranin of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for acrogranin Antibody (2A3C5). This work is in progress.
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SEE ALSO...
Acrogranin Antibody (2A3C5) is a mouse monoclonal IgG1 antibody that detects acrogranin in human samples through western blotting (WB). Acrogranin, also known as PC cell-derived growth factor (PCDGF), epithelin/granulin precursor, or paragranulin, is a glycosylated protein originally isolated from the highly tumorigenic, insulin-independent mouse teratoma PC cell line. This cysteine-rich molecule plays a crucial role in tumorigenicity, particularly in teratoma cells, and is expressed in various human breast cancer cell lines, including estrogen receptor-positive MDA-MB-468, MCF7, and T-47D cells. Acrogranin′s significance extends beyond its role as a growth factor; acrogranin is secreted and functions as an autocrine growth factor for breast carcinoma cells, with overexpression potentially contributing to the progression of human breast cancer. Notably, acrogranin interacts with specific proteins involved in cell signaling pathways, which can influence cellular proliferation and survival, making acrogranin a critical target for understanding tumor biology and developing therapeutic strategies. Anti-acrogranin antibody (2A3C5) serves as an essential tool for researchers investigating the molecular mechanisms underlying breast cancer and the role of acrogranin in tumor development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
acrogranin Antibody (2A3C5) | sc-81151 | 200 µg/ml | $322.00 |