ACOX2 Antibody (D-10): sc-374251
- ACOX2 Antibody (D-10) is a mouse monoclonal IgG1 κ ACOX2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 9-37 near the N-terminus of ACOX2 of human origin
- ACOX2 Antibody (D-10) is recommended for detection of ACOX2 of human origin by WB, IP, IF and ELISA
- Anti-ACOX2 Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ACOX2 Antibody (D-10) for WB applications. These reagents are now offered in bundles with ACOX2 Antibody (D-10) (see ordering information below).
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ACOX2 Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACOX2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACOX2 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACOX2, or acyl-Coenzyme A oxidase 2, is a 681 amino acid protein localized in the peroxisome and belongs to the acyl-CoA oxidase family. ACOX2 plays a crucial role in metabolizing branched-chain fatty acids and bile acid intermediates, facilitating their degradation within peroxisomes. Proper functioning of ACOX2 is vital for lipid metabolism and energy homeostasis, as defects can lead to severe metabolic disorders, including Zellweger syndrome, a rare congenital condition characterized by the absence of functional peroxisomes, often resulting in early mortality. ACOX2 exists as a heterodimer and utilizes flavin adenine dinucleotide (FAD) as a cofactor to catalyze oxidation reactions, underscoring ACOX2′s importance in cellular metabolism and potential consequences of dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ACOX2 Antibody (D-10) References:
- Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis. | Yeh, CS., et al. 2006. Cancer Lett. 233: 297-308. PMID: 15885896
- Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. | Nenicu, A., et al. 2007. Biol Reprod. 77: 1060-72. PMID: 17881773
- The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney. | Vanhove, GF., et al. 1993. J Biol Chem. 268: 10335-44. PMID: 8387517
- Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome. | Baumgart, E., et al. 1996. Proc Natl Acad Sci U S A. 93: 13748-53. PMID: 8943006
- Mammalian peroxisomal acyl-CoA oxidases. III. Molecular characterization of human branched chain fatty acyl-CoA oxidase. | Baumgart, E., et al. 1996. Ann N Y Acad Sci. 804: 678-9. PMID: 8993592
- Assignment of the human peroxisomal branched-chain acyl-CoA oxidase gene to chromosome 3p21.1-p14.2 by rodent/human somatic cell hybridization. | Moghrabi, NN., et al. 1997. Biochem Biophys Res Commun. 231: 767-9. PMID: 9070889
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACOX2 Antibody (D-10) | sc-374251 | 200 µg/ml | $316.00 | |||
ACOX2 Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-527446 | 200 µg Ab; 10 µg BP | $354.00 | |||
ACOX2 Antibody (D-10): m-IgG1 BP-HRP Bundle | sc-532819 | 200 µg Ab; 20 µg BP | $354.00 | |||
ACOX2 Antibody (D-10) AC | sc-374251 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ACOX2 Antibody (D-10) HRP | sc-374251 HRP | 200 µg/ml | $316.00 | |||
ACOX2 Antibody (D-10) FITC | sc-374251 FITC | 200 µg/ml | $330.00 | |||
ACOX2 Antibody (D-10) PE | sc-374251 PE | 200 µg/ml | $343.00 | |||
ACOX2 Antibody (D-10) Alexa Fluor® 488 | sc-374251 AF488 | 200 µg/ml | $357.00 | |||
ACOX2 Antibody (D-10) Alexa Fluor® 546 | sc-374251 AF546 | 200 µg/ml | $357.00 | |||
ACOX2 Antibody (D-10) Alexa Fluor® 594 | sc-374251 AF594 | 200 µg/ml | $357.00 | |||
ACOX2 Antibody (D-10) Alexa Fluor® 647 | sc-374251 AF647 | 200 µg/ml | $357.00 | |||
ACOX2 Antibody (D-10) Alexa Fluor® 680 | sc-374251 AF680 | 200 µg/ml | $357.00 | |||
ACOX2 Antibody (D-10) Alexa Fluor® 790 | sc-374251 AF790 | 200 µg/ml | $357.00 | |||
ACOX2 (D-10) Neutralizing Peptide | sc-374251 P | 100 µg/0.5 ml | $68.00 |