Acidic Cytokeratin Antibody (5F156): sc-70311

Acidic Cytokeratin Antibody (5F156) is a mouse monoclonal IgG1 kappa light chain antibody that detects Acidic Cytokeratin in mouse, rat, human, bovine, and rabbit samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Acidic Cytokeratin antibody (5F156) is available as a non-conjugated format. Acidic Cytokeratin belongs to the cytokeratin family, comprising diverse intermediate filament proteins essential for epithelial cell structural integrity. Acidic Cytokeratin predominantly resides in epithelial cell cytoplasm, forming a supportive network that resists mechanical stress and provides cellular resilience. Acidic Cytokeratin plays a vital role in epithelial tissue differentiation and specialization, particularly in epidermis and epithelial layer formation. Acidic Cytokeratin expression serves as a valuable marker for tissue differentiation, making Acidic Cytokeratin (5F156) monoclonal antibody instrumental in characterizing malignant tumors. Using anti-Acidic Cytokeratin antibody (5F156) across various applications helps researchers understand cellular dynamics and pathology in epithelial tissues, advancing knowledge of normal physiology and disease states.

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Acidic Cytokeratin Antibody (5F156) References:

1. Immunocytochemistry of cytokeratins in primary human liver tumors.  |  Van Eyken, P., et al. 1991. APMIS Suppl. 23: 77-85. PMID: 1715730
2. Keratin antigens in differentiating skin.  |  Lane, EB., et al. 1985. Ann N Y Acad Sci. 455: 241-58. PMID: 2417515
3. Differential diagnosis of gastrointestinal carcinomas by using monoclonal antibodies specific for individual keratin polypeptides.  |  Osborn, M., et al. 1986. Lab Invest. 55: 497-504. PMID: 2429069
4. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.  |  Moll, R., et al. 1982. Cell. 31: 11-24. PMID: 6186379
5. Identification of two types of keratin polypeptides within the acidic cytokeratin subfamily I.  |  Jorcano, JL., et al. 1984. J Mol Biol. 179: 257-81. PMID: 6209405
6. Expression of stratified squamous epithelia-type cytokeratin by canine mammary epithelial cells during tumorigenesis: type I (acidic) 57 kilodalton cytokeratin could be a molecular marker for malignant transformation of mammary epithelial cells.  |  Arai, K., et al. 1994. J Vet Med Sci. 56: 51-8. PMID: 7515697
7. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview.  |  van der Velden, LA., et al. 1993. Head Neck. 15: 133-46. PMID: 7680025
8. Keratins and the skin.  |  Fuchs, E. 1995. Annu Rev Cell Dev Biol. 11: 123-53. PMID: 8689554
9. Cytokeratin expression, fibrillar organization, and subtle function in liver cells.  |  Marceau, N. and Loranger, A. 1995. Biochem Cell Biol. 73: 619-25. PMID: 8714681

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Acidic Cytokeratin Antibody (5F156) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Acidic Cytokeratin Antibody (5F156) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Acidic Cytokeratin Antibody (5F156) Specifications

Alternate Product Name: CK10, CK12, CK13, CK14, CK16, CK17, CK18, CK19, and CK20

Product Clone Name: 5F156

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Acidic Cytokeratin

Epitope Species: human

Product Reactivity/Detection: most acidic (type I) cytokeratins

Species Reactivity/Detection: mouse, rat, human, bovine, rabbit

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Acidic Cytokeratin Antibody (5F156): N/A