Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (168): sc-65822
- Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (168) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRγ/ε of Torpedo, Xenopus, Rana and bovine origin by WB, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (168). This work is in progress.
AChRγ/ε Antibody (168) is a rat monoclonal IgG1 antibody that detects AChRγ/ε in Torpedo, Xenopus, Rana, and bovine species by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). AChRγ and AChRε are integral components of the nicotinic acetylcholine receptor family, which plays a crucial role in neuromuscular transmission and synaptic signaling. These receptors are primarily located at the postsynaptic membrane of the neuromuscular junction and central nervous system synapses, where rapid signal transmission occurs through ion flow via transmembrane aqueous pores upon acetylcholine binding. Proper functioning of AChRγ and AChRε remains vital for muscle contraction and overall neuromuscular health, as mutations in genes encoding these proteins can lead to severe conditions such as Escobar syndrome and congenital myasthenic syndrome. Anti-AChRγ/ε antibody (168) serves as an essential tool for researchers studying these receptors′ roles in synaptic transmission and implications in neuromuscular disorders, enabling reliable detection and analysis in various experimental settings.
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Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (168) References:
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- Effect of electroacupuncture on the expression of agrin and acetylcholine receptor subtypes in rats with tibialis anterior muscular atrophy induced by sciatic nerve injection injury. | Yu, J., et al. 2017. Acupunct Med. 35: 268-275. PMID: 28069562
- Collagen VI is required for the structural and functional integrity of the neuromuscular junction. | Cescon, M., et al. 2018. Acta Neuropathol. 136: 483-499. PMID: 29752552
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- Modification of Neuromuscular Junction Protein Expression by Exercise and Doxorubicin. | Huertas, AM., et al. 2020. Med Sci Sports Exerc. 52: 1477-1484. PMID: 31985575
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (168) | sc-65822 | 200 µg/ml | $316.00 |