Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (154): sc-65823

AChRγ/ε Antibody (154) is a rat monoclonal IgG1 antibody that detects AChRγ/ε in Torpedo, Xenopus, Rana, and canine species through applications such as western blotting (WB) and immunofluorescence (IF). AChRγ and AChRε are integral members of the nicotinic acetylcholine receptor family, which are crucial for neuromuscular transmission and synaptic plasticity. These receptors are primarily located at the postsynaptic membrane of the neuromuscular junction and in the central nervous system, where they facilitate rapid signal transmission by allowing ions to flow through their transmembrane aqueous pore upon binding with acetylcholine. The structural integrity of these receptors is vital, as they are composed of five homologous subunits that undergo conformational changes in response to neurotransmitter binding, thus enabling precise regulation of synaptic activity. The importance of AChRγ and AChRε extends beyond their role in neurotransmission; mutations in the gene encoding AChRγ have been linked to Escobar syndrome and a lethal form of multiple pterygium syndrome, while mutations in the gene for AChRε are associated with congenital myasthenic syndrome. Anti-AChRγ/ε antibody (154) is an essential tool for researchers studying these critical pathways and their implications in neuromuscular disorders.

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Nicotinic Acetylcholine Receptor gamma/epsilon/CHRNG/CHRNE Antibody (154) References:

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The preferred Nicotinic Acetylcholine Receptor gamma/CHRNG antibody is Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (145): sc-65759.