Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (67): sc-65764
- Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (67) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against intact AChR from fetal muscle of bovine origin
- recommended for detection of nicotinic AChRγ of bovine origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (67). This work is in progress.
AChRγ Antibody (67) is a rat monoclonal IgG1 antibody that detects AChRγ in bovine samples through applications such as western blotting (WB) and immunofluorescence (IF). AChRγ, a 517 amino acid member of the acetylcholine receptor family, is crucial for ligand binding and plays a significant role in neuromuscular organogenesis, making AChRγ essential for proper muscle function and development. AChRγ is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRγ interacts with acetylcholine to facilitate ion flow across the membrane, thereby initiating muscle contraction. Proper functioning of AChRγ is vital, as mutations in the gene encoding AChRγ can lead to severe conditions such as Escobar syndrome and a lethal form of multiple pterygium syndrome, highlighting AChRγ′s importance in both health and disease. Anti-AChRγ antibody (67) is an invaluable tool for researchers studying neuromuscular disorders and the underlying mechanisms of synaptic transmission.
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Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (67) References:
- Neuromuscular function and polymorphism of the acetylcholine receptor gamma gene. | Degli-Esposti, MA., et al. 1992. Muscle Nerve. 15: 543-9. PMID: 1350063
- Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes. | Lu, G., et al. 2005. J Biol Chem. 280: 21731-8. PMID: 15824106
- Effect of sera from AChR-antibody negative myasthenia gravis patients on AChR and MuSK in cell cultures. | Farrugia, ME., et al. 2007. J Neuroimmunol. 185: 136-44. PMID: 17335909
- AChR channel conversion and AChR-adjusted neuronal survival during embryonic development. | Yampolsky, P., et al. 2008. Mol Cell Neurosci. 37: 634-45. PMID: 18226545
- Fetal acetylcholine receptor inactivation syndrome: A myopathy due to maternal antibodies. | Hacohen, Y., et al. 2015. Neurol Neuroimmunol Neuroinflamm. 2: e57. PMID: 25566546
- Defective Acetylcholine Receptor Subunit Switch Precedes Atrophy of Slow-Twitch Skeletal Muscle Fibers Lacking ERK1/2 Kinases in Soleus Muscle. | Wang, S., et al. 2016. Sci Rep. 6: 38745. PMID: 27934942
- Collagen VI is required for the structural and functional integrity of the neuromuscular junction. | Cescon, M., et al. 2018. Acta Neuropathol. 136: 483-499. PMID: 29752552
- Identification of a determinant of acetylcholine receptor gating kinetics in the extracellular portion of the gamma subunit. | Fucile, S., et al. 1996. Eur J Neurosci. 8: 2564-70. PMID: 8996805
- The fetal form of the acetylcholine receptor distinguishes rhabdomyosarcomas from other childhood tumors. | Gattenloehner, S., et al. 1998. Am J Pathol. 152: 437-44. PMID: 9466570
- Muscle-specific agrin isoforms reduce phosphorylation of AChR gamma and delta subunits in cultured muscle cells. | Meier, T., et al. 1998. Mol Cell Neurosci. 11: 206-16. PMID: 9675052
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (67) | sc-65764 | 200 µg/ml | $316.00 |