Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (66): sc-58597
- Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (66) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against full length native AChRγ of bovine origin
- recommended for detection of nicotinic AChRγ of human and bovine origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (66). This work is in progress.
AChRγ Antibody (66) is a rat monoclonal IgG2a antibody that detects AChRγ in human and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AChRγ, a 517 amino acid member of the acetylcholine receptor family, is crucial for ligand binding and neuromuscular organogenesis, highlighting its importance in the development and function of the neuromuscular junction. AChRγ is primarily located at the postsynaptic membrane, where AChRγ plays a vital role in synaptic transmission by allowing the flow of ions in response to acetylcholine binding. The proper functioning of AChRγ is essential for muscle contraction and overall neuromuscular health, as mutations in the gene encoding AChRγ can lead to severe conditions such as Escobar syndrome and a lethal form of multiple pterygium syndrome. Anti-AChRγ antibody (66) is an invaluable tool for researchers studying these critical pathways and the implications of receptor dysfunction in various diseases.
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Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (66) References:
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- Muscle LIM protein promotes expression of the acetylcholine receptor gamma-subunit gene cooperatively with the myogenin-E12 complex. | Lu, PY., et al. 2004. Cell Mol Life Sci. 61: 2386-92. PMID: 15378207
- Different mechanisms regulate muscle-specific AChR gamma- and epsilon-subunit gene expression. | Numberger, M., et al. 1991. EMBO J. 10: 2957-64. PMID: 1655408
- Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning. | Liu, Y., et al. 2008. Development. 135: 1957-67. PMID: 18434415
- Ocular and generalized myasthenia gravis induced by human acetylcholine receptor γ subunit immunization. | Wu, X., et al. 2012. Muscle Nerve. 45: 209-16. PMID: 22246876
- Modification of Neuromuscular Junction Protein Expression by Exercise and Doxorubicin. | Huertas, AM., et al. 2020. Med Sci Sports Exerc. 52: 1477-1484. PMID: 31985575
- Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases. | Yamamotoya, T., et al. 2022. Sci Rep. 12: 1966. PMID: 35121777
- Impaired gating of γ- and ε-AChR respectively causes Escobar syndrome and fast-channel myasthenia. | Shen, XM., et al. 2023. Ann Clin Transl Neurol. 10: 732-743. PMID: 36891870
- Monoclonal antibodies against the acetylcholine receptor gamma-subunit as site specific probes for receptor tyrosine phosphorylation. | Tzartos, SJ., et al. 1995. FEBS Lett. 363: 195-8. PMID: 7537227
- Maturation of the acetylcholine receptor in skeletal muscle: regulation of the AChR gamma-to-epsilon switch. | Missias, AC., et al. 1996. Dev Biol. 179: 223-38. PMID: 8873766
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor gamma/CHRNG Antibody (66) | sc-58597 | 200 µg/ml | $316.00 |