Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148): sc-65813

AChRβ1 Antibody (148) is a rat monoclonal IgG2a antibody that detects AChRβ1 of mouse, rat, human, bovine, Torpedo, Rana, and Xenopus origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRβ1 (148) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AChRβ1, also known as CHRNB1, is a critical component of the nicotinic acetylcholine receptor, playing a vital role in synaptic transmission at the neuromuscular junction. This receptor comprises five homologous subunits forming a transmembrane aqueous pore, allowing ion passage when activated by acetylcholine. Proper functioning of AChRβ1 is essential for muscle contraction and overall neuromuscular function, facilitating rapid signal transmission from nerve cells to muscle fibers. Mutations or defects in the gene encoding AChRβ1 can lead to congenital myasthenic syndrome slow-channel type (SCCMS), a condition characterized by muscle weakness affecting various muscle groups, including those responsible for eye movement and facial expressions. Understanding AChRβ1 role in synaptic transmission is crucial for developing therapeutic strategies for neuromuscular disorders.

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Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148) References:

1. Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy.  |  Baenziger, JE., et al. 1992. Biophys J. 62: 64-6. PMID: 1600101
2. Ligand-gated ion channels in the brain: the amino acid receptor superfamily.  |  Betz, H. 1990. Neuron. 5: 383-92. PMID: 1698394
3. Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel.  |  Alkondon, M., et al. 1988. J Pharmacol Exp Ther. 245: 543-56. PMID: 2452874
4. Neurotransmitter action: opening of ligand-gated ion channels.  |  Unwin, N. 1993. Cell. 72 Suppl: 31-41. PMID: 7679054
5. The diversity of neuronal nicotinic acetylcholine receptors.  |  Sargent, PB. 1993. Annu Rev Neurosci. 16: 403-43. PMID: 7681637
6. Quantal release of neurotransmitter and long-term potentiation.  |  Stevens, CF. 1993. Cell. 72 Suppl: 55-63. PMID: 8094037
7. The role of NMDA receptors in information processing.  |  Daw, NW., et al. 1993. Annu Rev Neurosci. 16: 207-22. PMID: 8460891
8. Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.  |  Ramirez-Latorre, J., et al. 1996. Nature. 380: 347-51. PMID: 8598930

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148) Specifications

Alternate Product Name: CHRNB1

Product Clone Name: 148

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: AChR

Epitope Species: Torpedo

Product Reactivity/Detection: nicotinic AChRβ1 cytoplasmic domain

Species Reactivity/Detection: mouse, rat, human, bovine, Torpedo, Rana, Xenopus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin