Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (123): sc-65790
- Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (123) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRβ1 of mouse, rat, human, bovine and Torpedo origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (123). This work is in progress.
AChRβ1 Antibody (123) is a rat monoclonal IgG1 antibody that detects AChRβ1 in mouse, rat, human, bovine, and Torpedo by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRβ1, also known as CHRNB, CMS1D, CMS2A, SCCMS, or CHRNB1, is a crucial component of the nicotinic acetylcholine receptor, which plays a vital role in synaptic transmission at the neuromuscular junction. This 501 amino acid protein is part of the ligand-gated ion channel family and is essential for the rapid communication between nerve and muscle cells. The AChRβ1 subunit contributes to the formation of the receptor′s transmembrane aqueous pore, allowing ions to flow in response to acetylcholine binding, which is critical for muscle contraction and overall neuromuscular function. Defects in the gene encoding AChRβ1 can lead to congenital myasthenic syndrome slow-channel type (SCCMS), a condition characterized by muscle weakness that affects various muscle groups, including those responsible for eye movement and facial expressions. Anti-AChRβ1 antibody (123) effectively detects AChRβ1 across multiple species, making this reagent an invaluable tool for researchers studying neuromuscular disorders and the underlying mechanisms of synaptic transmission.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (123) | sc-65790 | 200 µg/ml | $316.00 |