Nicotinic Acetylcholine Receptor alpha 8/CHRNA8 Antibody (305): sc-58608
- Nicotinic Acetylcholine Receptor alpha 8/CHRNA8 Antibody (305) is a rat monoclonal IgG2c provided at 200 µg/ml
- raised against full length native AChRα8 of chicken origin
- recommended for detection of native nicotinic AChRα8 of avian origin by IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 8/CHRNA8 Antibody (305). This work is in progress.
AChRα8 Antibody (305) is a rat monoclonal IgG2c antibody that detects AChRα8 in avian species through applications such as immunoprecipitation (IP) and enzyme-linked immunosorbent assay (ELISA). AChRα8 is a crucial component of the ligand-gated ion channel receptor family, functioning as a multi-pass membrane protein composed of 456 amino acids. AChRα8 plays a significant role in neurotransmission by forming a transmembrane aqueous pore that allows ions to flow in response to the binding of neurotransmitters, such as acetylcholine. AChRα8 is vital for synaptic transmission, particularly at the neuromuscular junction, where AChRα8 facilitates muscle contraction. Additionally, AChRα8′s interaction with other proteins, such as scaffolding proteins and signaling molecules, is essential for maintaining receptor localization and function, thereby influencing synaptic plasticity and overall neural communication. AChRα8′s ability to undergo conformational changes upon neurotransmitter binding underscores AChRα8′s importance in rapid signal transduction, making AChRα8 a key target for research in neurobiology and pharmacology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 8/CHRNA8 Antibody (305) | sc-58608 | 200 µg/ml | $322.00 |