Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 Antibody (299): sc-65862

AChRα4 Antibody (299) is a rat monoclonal IgG1 antibody that detects AChRα4 in mouse, rat, human, and chicken samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRα4, also known by various aliases including EBN, BFNC, EBN1, NACHR, NACRA4, and CHRNA4, is a 627 amino acid multi-pass membrane protein that plays a crucial role in nicotinic acetylcholine receptor function, essential for fast synaptic transmission in the nervous system. Nicotinic acetylcholine receptors are located at the postsynaptic membrane of the neuromuscular junction and in the central nervous system, where these receptors mediate acetylcholine effects, a key neurotransmitter involved in muscle contraction and neuronal signaling. Proper functioning of AChRα4 is vital, as mutations or dysregulation can lead to conditions such as nocturnal frontal lobe epilepsy type 1 (ENFL1), an autosomal dominant disorder characterized by nocturnal seizures and abnormal movements. Understanding AChRα4 structure and function is important for developing therapeutic strategies for related neurological disorders, making anti-AChRα4 antibody (299) an invaluable tool for researchers studying synaptic transmission and receptor function.

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Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 Antibody (299) References:

1. Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems.  |  Todd, RD., et al. 2003. Mol Psychiatry. 8: 103-8. PMID: 12556914
2. The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2.  |  Pilz, AJ., et al. 1992. Ann Hum Genet. 56: 289-93. PMID: 1492743
3. Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients.  |  Kim, SA., et al. 2004. Alcohol. 34: 115-20. PMID: 15902904
4. The nicotinic acetylcholine receptor alpha 4 subunit contains a functionally relevant SNP Haplotype.  |  Eggert, M., et al. 2015. BMC Genet. 16: 46. PMID: 25934188
5. Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens.  |  Yu, M., et al. 2024. Animals (Basel). 14: PMID: 39457933
6. Gene expression of the nicotinic acetylcholine receptor alpha 4 subunit in the frontal cortex in Parkinson's disease patients.  |  Schröder, H., et al. 1995. Neurosci Lett. 187: 173-6. PMID: 7624020
7. Refinement of the localization of the gene for neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) to human chromosome 20q13.2-q13.3.  |  Steinlein, O., et al. 1994. Genomics. 22: 493-5. PMID: 7806245
8. Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4).  |  Steinlein, O., et al. 1996. Genomics. 32: 289-94. PMID: 8833159
9. Differential co-expression of nicotinic acetylcholine receptor alpha 4 and beta 2 subunit genes in various regions of rat brain.  |  Liu, C., et al. 1996. Neuroreport. 7: 1645-9. PMID: 8904774
10. Neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and panic disorder: an association study.  |  Steinlein, OK., et al. 1997. Am J Med Genet. 74: 199-201. PMID: 9129724

The preferred Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 antibody is Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 Antibody (A-6): sc-74519.