Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (65): sc-65825

AChRα1 Antibody (65) is a rat monoclonal IgG1 antibody that detects AChRα1 in bovine samples through western blotting (WB) and immunofluorescence (IF) applications. AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial multi-pass membrane protein composed of 482 amino acids, which plays a significant role in neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating the influx of ions through its transmembrane pore. Proper functioning of AChRα1 is vital for muscle contraction and overall neuromuscular function, as AChRα1 directly influences synaptic transmission. Notably, AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms underscores the importance of AChRα1 in both muscle and neuronal signaling pathways, making AChRα1 a key target for research into neuromuscular disorders and synaptic function. Anti-AChRα1 antibody (65) is an essential tool for researchers aiming to explore the intricate mechanisms of neurotransmission and muscle physiology in bovine models.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (65) References:

1. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value.  |  Chianello Nicolau, M., et al. 2016. World J Gastroenterol. 22: 7146-56. PMID: 27610024
2. Molecular characterization of congenital myasthenic syndromes in Spain.  |  Natera-de Benito, D., et al. 2017. Neuromuscul Disord. 27: 1087-1098. PMID: 29054425
3. Physiological Expression of Ion Channel Receptors in Human Periodontal Ligament Stem Cells.  |  Chiricosta, L., et al. 2019. Cells. 8: PMID: 30845727
4. α-Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles.  |  Machado, J., et al. 2019. Mol Metab. 28: 91-106. PMID: 31331823
5. Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.  |  Rahman, MM., et al. 2020. Neuron. 106: 952-962.e5. PMID: 32275860
6. Congenital myasthenic syndrome: Correlation between clinical features and molecular diagnosis.  |  Estephan, EP., et al. 2022. Eur J Neurol. 29: 833-842. PMID: 34749429
7. Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis.  |  Lin, JB., et al. 2022. Ann Clin Transl Neurol. 9: 786-794. PMID: 35393764
8. The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors.  |  Nys, M., et al. 2022. Nat Commun. 13: 4543. PMID: 35927270
9. CHRNA1 and its correlated-myogenesis/cell cycle genes are prognosis-related markers of metastatic melanoma.  |  Bakr, MN., et al. 2023. Biochem Biophys Rep. 33: 101425. PMID: 36654921
10. PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.  |  Chen, JF., et al. 2023. Orphanet J Rare Dis. 18: 205. PMID: 37542348

The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.