Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (61): sc-58602

AChRα1 Antibody (61) is a rat monoclonal IgG2a antibody that detects AChRα1 in mouse, rat, human, and Electrophorus electricus by immunoprecipitation (IP) and immunofluorescence (IF) applications. AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a critical component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission at the neuromuscular junction. This 482 amino acid multi-pass membrane protein exists as two alternatively spliced isoforms, with isoform 1 being specifically expressed in skeletal muscle and isoform 2 being constitutively expressed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The presence of these isoforms contributes to the diverse physiological functions of AChRα1, particularly in muscle contraction and synaptic transmission. AChRα1′s ability to undergo conformational changes in response to acetylcholine binding is essential for rapid signal transmission across the synapse, making AChRα1 a key player in both voluntary and involuntary muscle control. Additionally, acetylcholinesterase tightly regulates AChRα1 activity, ensuring precise neurotransmission control and preventing excessive stimulation of the postsynaptic membrane. Anti-AChRα1 antibody (61) serves as an invaluable tool for researchers studying synaptic transmission dynamics and nicotinic receptor roles in various physiological and pathological conditions.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (61) References:

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The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.