Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (47): sc-65846
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (47) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against AChR of Electrophorus origin
- recommended for detection of nicotinic AChRα1 of electrophorus, frog and goldfish origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (47). This work is in progress.
AChRα1 Antibody (47) is a rat monoclonal IgG2a antibody that detects AChRα1 in electrophorus, frog, and goldfish by western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial multi-pass membrane protein composed of 482 amino acids, which plays a significant role in neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating the influx of ions through its transmembrane pore. Proper functioning of AChRα1 is vital for muscle contraction and overall neuromuscular function, as AChRα1 directly influences synaptic transmission. Notably, AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms underscores the importance of AChRα1 in both muscle and neuronal signaling pathways, making AChRα1 a key target for research in neuromuscular disorders and synaptic function. Anti-AChRα1 antibody (47) is an essential tool for researchers aiming to explore the dynamics of this critical protein in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (47) | sc-65846 | 200 µg/ml | $322.00 |