Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (208): sc-65839
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (208) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against purifed muscle AChR of human origin
- recommended for detection of nicotinic AChRα1 of human and Torpedo origin by WB and IF
- See Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 (153): sc-65829 for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (208). This work is in progress.
AChRα1 Antibody (208) is a rat monoclonal IgG2a antibody that detects AChRα1 in human and Torpedo species by western blotting (WB) and immunofluorescence (IF) applications. AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial multi-pass membrane protein composed of 482 amino acids, which plays a vital role in neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating the influx of ions through its transmembrane aqueous pore. The proper functioning of AChRα1 is essential for muscle contraction and overall neuromuscular function, as AChRα1 allows for rapid communication between nerve cells and muscle fibers. Notably, AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. This broad expression pattern underscores the importance of AChRα1 in diverse physiological processes beyond muscle contraction, including roles in the central nervous system. The activity of AChRα1 is tightly regulated, with the termination of acetylcholine signaling mediated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine, ensuring precise control of synaptic transmission. Anti-AChRα1 antibody (208) is an invaluable tool for researchers studying the dynamics of neuromuscular signaling and the intricate mechanisms underlying synaptic transmission.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (208) References:
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (208) | sc-65839 | 200 µg/ml | $322.00 |