Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (203): sc-65837

AChRα1 Antibody (203) is a rat monoclonal IgG2a antibody that detects AChRα1 in human and Torpedo species by western blotting (WB) and immunofluorescence (IF) applications. AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial multi-pass membrane protein composed of 482 amino acids, which plays a significant role in neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating the influx of ions through its transmembrane pore. Proper functioning of AChRα1 is vital for muscle contraction and overall neuromuscular function, as AChRα1 directly influences synaptic transmission. Notably, AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms underscores the importance of AChRα1 in both muscle and neuronal signaling pathways, making AChRα1 a key target for research into neuromuscular disorders and synaptic function. Anti-AChRα1 antibody (203) is an essential tool for researchers investigating the dynamics of neurotransmission and the molecular mechanisms underlying muscle and nerve function.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (203) References:

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8. Discovery of piperonyl-tethered sulfoximines as novel low bee-toxicity aphicides targeting Amelα1/ratβ2 complex.  |  Han, Q., et al. 2023. Int J Biol Macromol. 253: 126719. PMID: 37678680
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The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.