Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (198): sc-65836

AChRα1 Antibody (198) is a rat monoclonal IgG2a antibody that recognizes AChRα1 in human, Torpedo, and chicken samples through western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial multi-pass membrane protein composed of 482 amino acids, which plays a significant role in neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating ion influx through a transmembrane pore. AChRα1 is vital for muscle contraction and overall neuromuscular function, directly influencing synaptic transmission. AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including brain, heart, kidney, liver, lung, and thymus. These diverse isoform expression patterns highlight AChRα1′s importance in both muscle and neuronal signaling pathways, making AChRα1 a key target for research in neuromuscular disorders and synaptic function.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (198) References:

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8. Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor.  |  Ning, J., et al. 2018. Mar Drugs. 16: PMID: 30551685
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10. Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation.  |  Zhang, X., et al. 2025. Respir Res. 26: 29. PMID: 39833797

The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.