Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (187): sc-65835
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (187) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRα1 of Torpedo origin by WB and IF
- See Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 (153): sc-65829 for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (187). This work is in progress.
AChRα1 Antibody (187) is a rat monoclonal IgG2a antibody that detects AChRα1 in Torpedo species through western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission. This multi-pass membrane protein consists of 482 amino acids and exists in two alternatively spliced isoforms, with isoform 1 being specifically expressed in skeletal muscle and isoform 2 found in a broader range of tissues, including skeletal muscle, brain, heart, kidney, liver, lung, and thymus. AChRα1 presence at the postsynaptic membrane of the neuromuscular junction is essential for muscle contraction, as AChRα1 binds acetylcholine and facilitates ion flow through its transmembrane pore, thereby initiating muscle action. AChRα1 functional significance is underscored by interactions with various proteins, including scaffolding proteins that help organize the receptor at the synapse, ensuring efficient signal transduction and muscle response. AChRα1 activity is tightly regulated, with the termination of acetylcholine signaling mediated by acetylcholinesterase, which hydrolyzes acetylcholine to prevent overstimulation. This regulation is critical for maintaining proper neuromuscular function and preventing disorders associated with receptor dysfunction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (187) | sc-65835 | 200 µg/ml | $322.00 |