Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (173): sc-65834
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (173) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRα1 of Torpedo origin by WB and IF
- See Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 (153): sc-65829 for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (173). This work is in progress.
AChRα1 Antibody (173) is a rat monoclonal IgG1 antibody that recognizes AChRα1 in Torpedo species through western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial 482 amino acid multi-pass membrane protein essential for neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating ion influx through its transmembrane pore. AChRα1 plays a vital role in muscle contraction and overall neuromuscular function by directly influencing synaptic transmission. AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms highlights AChRα1′s importance in both muscle and neuronal tissues, making AChRα1 a key target for studying neuromuscular disorders and synaptic function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (173) | sc-65834 | 200 µg/ml | $322.00 |