Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (149): sc-65842
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (149) is a rat monoclonal IgM provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRα1 of Torpedo, Rana and Xenopus origin by WB and IF
- See Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 (153): sc-65829 for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (149). This work is in progress.
AChRα1 Antibody (149) is a rat monoclonal IgM antibody that detects AChRα1 in Torpedo, Rana, and Xenopus species by western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial multi-pass membrane protein composed of 482 amino acids, which plays a vital role in neuromuscular transmission. AChRα1 is primarily located at the postsynaptic membrane of the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating the influx of ions through its transmembrane pore. Proper functioning of AChRα1 is essential for muscle contraction and overall neuromuscular function, as AChRα1 directly influences synaptic transmission. Notably, AChRα1 exists in two alternatively spliced isoforms; isoform 1 is exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms highlights AChRα1′s importance in both muscle and neuronal signaling pathways, making AChRα1 a significant target for research in neuromuscular disorders and synaptic function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (149) | sc-65842 | 200 µg/ml | $322.00 |