Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (147): sc-65841
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (147) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- recommended for detection of nicotinic AChRα1 of Torpedo, Rana and Xenopus origin by WB, IP and IF
- See Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 (153): sc-65829 for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (147). This work is in progress.
AChRα1 Antibody (147) is a rat monoclonal IgG2a antibody that detects AChRα1 in Torpedo, Rana, and Xenopus species through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRα1, also known by various aliases including ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission. This 482 amino acid multi-pass membrane protein is integral to the postsynaptic membrane at the neuromuscular junction, where AChRα1 binds acetylcholine, facilitating the flow of ions through its transmembrane aqueous pore. AChRα1′s importance lies not only in its function of mediating synaptic transmission but also in its structural diversity, as AChRα1 exists in two alternatively spliced isoforms. Isoform 1 is specifically expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. This broad expression pattern underscores AChRα1′s significance in both muscle contraction and central nervous system signaling, making anti-AChRα1 antibody (147) an essential tool for researchers investigating the dynamics of neurotransmitter interactions and receptor functionality in these diverse biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (147) | sc-65841 | 200 µg/ml | $322.00 |