Molecular structure of Acetyl Podocarpic Acid Anhydride, CAS Number: 344327-48-6
Acetyl Podocarpic Acid Anhydride (CAS 344327-48-6)
Alternate Names:
acetyl-podocarpic dimer
Application:
Acetyl Podocarpic Acid Anhydride is a potent, semi-synthetic LXR (liver X receptor) agonist
CAS Number:
344327-48-6
Molecular Weight:
614.75
Molecular Formula:
C38H46O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acetyl podocarpic acid anhydride (APD) is a potent, semi-synthetic LXR (liver X receptor) agonist derived from extracts of the mayapple. Acetyl Podocarpic Acid Anhydride forms a heterodimer with the retinoid X receptor (RXR), and together these compounds, acting through LXR, induce the expression of the ABCA1 reverse cholesterol transporter and inhibit the overall absorption of cholesterol (ED50 = 1 nM). In transient transactivation assays, acetyl podocarpic acid anhydride was found to be approximately 1,000 times more potent than 22(R)-hydroxy cholesterol. Acetyl Podocarpic Acid Anhydride can be used as a positive control for the testing of LXR agonists.
Acetyl Podocarpic Acid Anhydride (CAS 344327-48-6) References
- Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. | Repa, JJ., et al. 2000. Science. 289: 1524-9. PMID: 10968783
- A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. | Sparrow, CP., et al. 2002. J Biol Chem. 277: 10021-7. PMID: 11790770
- Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. | Singh, SB., et al. 2005. Bioorg Med Chem Lett. 15: 2824-8. PMID: 15911262
- Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. | Jayasuriya, H., et al. 2005. J Nat Prod. 68: 1247-52. PMID: 16124770
- Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis. | Liu, W., et al. 2005. Bioorg Med Chem Lett. 15: 4574-8. PMID: 16125384
Activator of:
LXR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetyl Podocarpic Acid Anhydride, 1 mg | sc-221207 | 1 mg | $23.00 | |||
Acetyl Podocarpic Acid Anhydride, 5 mg | sc-221207A | 5 mg | $105.00 |