ACAA2 Antibody (192): sc-100847

ACAA2 Antibody (192) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACAA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-ACAA2 antibody (192) is available as the non-conjugated isotype antibody. ACAA2, or acetyl-Coenzyme A acyltransferase 2, is a crucial enzyme in lipid metabolism, specifically involved in the fatty acid oxidation pathway. This 397 amino acid protein is localized in the mitochondrion, where ACAA2 catalyzes the final step of converting acetyl-CoA to 3-oxoacyl-CoA, a vital reaction for energy production and metabolic regulation. ACAA2′s importance lies in maintaining cellular energy homeostasis, particularly in tissues with high energy demands such as the liver and muscle. Notably, ACAA2 features a unique N-terminal targeting signal that remains non-cleavable, distinguishing ACAA2 from other mitochondrial proteins and ensuring proper localization and function. With a high degree of conservation, human ACAA2 shares 86.6% amino acid identity with rat ACAA2, underscoring the evolutionary significance of this enzyme across species.

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ACAA2 Antibody (192) References:

1. Lipoprotein lipase activator NO-1886 (ibrolipim) accelerates the mRNA expression of fatty acid oxidation-related enzymes in rat liver.  |  Doi, M., et al. 2003. Metabolism. 52: 1547-50. PMID: 14669153
2. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.  |  Aboulaich, N., et al. 2004. Biochem J. 383: 237-48. PMID: 15242332
3. Chronic quercetin exposure affects fatty acid catabolism in rat lung.  |  de Boer, VC., et al. 2006. Cell Mol Life Sci. 63: 2847-58. PMID: 17103110
4. Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase.  |  Abe, H., et al. 1993. Biochim Biophys Acta. 1216: 304-6. PMID: 8241273

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACAA2 Antibody (192) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-ACAA2 Antibody (192) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACAA2 Antibody (192) Specifications

Alternate Product Name: ACAA2

Product Clone Name: 192

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 151-261

Epitope Target: ACAA2

Epitope Species: human

Product Reactivity/Detection: ACAA2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for ACAA2 Antibody (192): N/A