ABHD5 Antibody (C-8): sc-393949
- ABHD5 Antibody (C-8) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 10-29 near the N-terminus of ABHD5 of human origin
- recommended for detection of ABHD5 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ABHD5 Antibody (C-8) for WB applications. These reagents are now offered in bundles with ABHD5 Antibody (C-8) (see ordering information below).
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ABHD5 Antibody (C-8) is a mouse monoclonal IgG2b antibody that detects ABHD5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ABHD5, also known as abhydrolase domain containing 5, CGI-58, or NCIE2, is a 349 amino acid protein characterized by its alpha/beta-hydrolase domain, which is essential for catalytic activity. ABHD5 is primarily localized to the surface of lipid droplets, where ABHD5 plays a crucial role in lipolysis, the process of breaking down fats. By interacting with Perilipin, ABHD5 facilitates the mobilization of stored lipids, making ABHD5 vital for maintaining lipid homeostasis in the body. Disruptions in the ABHD5 gene can lead to Chanarin-Dorfman syndrome, a serious autosomal recessive disorder that affects lipid metabolism and results in a range of symptoms, including congenital generalized ichthyosis, vacuolated leukocytes, hepatomegaly, myopathy, cataracts, neurosensory hearing loss, and developmental delays. Anti-ABHD5 antibody (C-8) is an invaluable tool for researchers studying lipid metabolism and related disorders, providing insights into ABHD5′s function and implications in human health.
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ABHD5 Antibody (C-8) References:
- Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl). | Granneman, JG., et al. 2009. J Biol Chem. 284: 34538-44. PMID: 19850935
- Molecular analysis of Chanarin-Dorfman syndrome (CDS) patients: Identification of novel mutations in the ABHD5 gene. | Emre, S., et al. 2010. Eur J Med Genet. 53: 141-4. PMID: 20307695
- CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. | Lord, CC., et al. 2012. Diabetes. 61: 355-63. PMID: 22228714
- Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5. | Mitra, R., et al. 2017. BMC Cancer. 17: 631. PMID: 28877685
- Inherited non-alcoholic fatty liver disease and dyslipidemia due to monoallelic ABHD5 mutations. | Youssefian, L., et al. 2019. J Hepatol. 71: 366-370. PMID: 30954460
- ABHD5 cleaves HDAC4 to benefit the heart. | Travers, JG. and McKinsey, TA. 2019. Nat Metab. 1: 1034-1035. PMID: 32694866
- Circular RNA cMras Suppresses the Progression of Lung Adenocarcinoma Through ABHD5/ATGL Axis Using NF-κB Signaling Pathway. | Zhou, Q. and Sun, Y. 2023. Cancer Biother Radiopharm. 38: 336-346. PMID: 32822232
- Transcription Factors ZEB1 and CREB Promote the Transcription of Bovine ABHD5 Gene. | Wang, X., et al. 2021. DNA Cell Biol. 40: 219-230. PMID: 33332227
- A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands. | Mottillo, EP., et al. 2023. Cell Rep Methods. 3: 100394. PMID: 36936069
- Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis. | Teskey, G., et al. 2025. J Biol Chem. 301: 108186. PMID: 39814233
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABHD5 Antibody (C-8) | sc-393949 | 200 µg/ml | $322.00 | |||
ABHD5 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-538342 | 200 µg Ab; 10 µg BP | $361.00 | |||
ABHD5 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-535935 | 200 µg Ab; 40 µg BP | $361.00 | |||
ABHD5 Antibody (C-8): m-IgG2b BP-HRP Bundle | sc-549940 | 200 µg Ab; 10 µg BP | $361.00 | |||
ABHD5 (C-8) Neutralizing Peptide | sc-393949 P | 100 µg/0.5 ml | $69.00 |