ABHD14B Antibody (E-12): sc-515084

ABHD14B Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects ABHD14B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ABHD14B antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ABHD14B protein, consisting of 210 amino acids, is crucial for various biochemical processes and is localized in both cytoplasm and nucleus, where ABHD14B exists as two alternatively spliced isoforms. This localization enables ABHD14B to participate in diverse cellular functions, including lipid metabolism and signaling pathways essential for maintaining cellular homeostasis. Members of the α/β hydrolase superfamily, to which ABHD14B belongs, are often implicated in various diseases, making these proteins important drug targets. The ABHD gene subfamily, which includes ABHD14B, consists of 15 mostly uncharacterized members, with some, like ABHD1 and ABHD2, playing roles in metabolizing xenobiotics and atherosclerosis development, respectively. Understanding ABHD14B function and localization can provide insights into potential roles in health and disease, particularly in conditions such as diabetes and neurodegenerative disorders.

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ABHD14B Antibody (E-12) References:

1. Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B.  |  Padmanabhan, B., et al. 2000. Acta Crystallogr D Biol Crystallogr. 56: 1479-81. PMID: 11053859
2. Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome.  |  Lefèvre, C., et al. 2001. Am J Hum Genet. 69: 1002-12. PMID: 11590543
3. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.  |  Edgar, AJ. and Polak, JM. 2002. Biochem Biophys Res Commun. 292: 617-25. PMID: 11922611
4. Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms.  |  Holmquist, M. 2000. Curr Protein Pept Sci. 1: 209-35. PMID: 12369917
5. The alpha/beta hydrolase fold.  |  Ollis, DL., et al. 1992. Protein Eng. 5: 197-211. PMID: 1409539
6. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.  |  Simon, GM. and Cravatt, BF. 2006. J Biol Chem. 281: 26465-72. PMID: 16818490
7. Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.  |  Miyata, K., et al. 2008. Biochem Biophys Res Commun. 365: 207-13. PMID: 17980156
8. An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines.  |  Li, F., et al. 2009. Mol Biol Rep. 36: 691-6. PMID: 18360779
9. Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme.  |  Rajendran, A., et al. 2020. Biochemistry. 59: 183-196. PMID: 31478652
10. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals.  |  Rajendran, A., et al. 2022. J Biol Chem. 298: 102128. PMID: 35700823
11. In-depth proteomic signature of parathyroid carcinoma.  |  Kong, SH., et al. 2023. Eur J Endocrinol. 188: 385-394. PMID: 36995894
12. Identification of sequence determinants for the ABHD14 enzymes.  |  Vaidya, K., et al. 2025. Proteins. 93: 255-266. PMID: 37974539

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ABHD14B Antibody (E-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ABHD14B Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ABHD14B Antibody (E-12) Specifications

Alternate Product Name: ABHD14B

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 156-207

Epitope Target: ABHD14B

Epitope Species: human

Product Reactivity/Detection: ABHD14B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ABHD14B Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin