ABCF1 Antibody (ABC5H06): sc-81047

ABCF1 Antibody (ABC5H06) is a mouse monoclonal IgG1 antibody that detects ABCF1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. ABCF1, or ATP-binding cassette sub-family F member 1, is a crucial 845 amino acid protein encoded by the human gene ABCF1, which plays a significant role in mRNA translation by interacting with eukaryotic initiation factor 2 (eIF2) and is also associated with ribosomes. This interaction is vital for the regulation of protein synthesis, particularly under stress conditions, as ABCF1 helps modulate the translation of specific mRNAs in response to cellular signals. Notably, ABCF1 is part of the ABC transporter family, specifically the EF3 subfamily, and is unique among its peers due to the absence of transmembrane domains typically found in other ABC transporters. Instead, ABCF1 functions in a more regulatory capacity, influencing the translation process rather than transporting molecules across membranes. ABCF1 is ubiquitously expressed in human tissues and can be induced by tumor necrosis factor (TNF), highlighting ABCF1′s importance in inflammatory responses. Additionally, upon DNA damage, ABCF1 undergoes phosphorylation by either ATM or ATR, which may further implicate ABCF1 in cellular stress responses and the maintenance of genomic integrity. Anti-ABCF1 antibody (ABC5H06) is an essential tool for researchers studying the intricate roles of ABCF1 in cellular processes and its potential implications in disease mechanisms.

The preferred ABCF1 antibody is ABCF1 Antibody (H-3): sc-377185.