ABCB9 Antibody (A-8): sc-393412
- ABCB9 Antibody (A-8) is a mouse monoclonal IgG1 κ ABCB9 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 409-708 mapping near the C-terminus of ABCB9 of human origin
- ABCB9 Antibody (A-8) is recommended for detection of ABCB9 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ABCB9 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ABCB9 Antibody (A-8) for WB applications. These reagents are now offered in bundles with ABCB9 Antibody (A-8) (see ordering information below).
ABCB9 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects ABCB9 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ABCB9 antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ABCB9, also known as Transporter associated with antigen processing-like (TAPL), plays a crucial role in the immune response by facilitating peptide transport into the endoplasmic reticulum, where peptides can be loaded onto major histocompatibility complex (MHC) class I molecules for presentation to CD8+ T cells. This function is vital for recognizing intracellular pathogens and tumor cells, making ABCB9 an important player in the adaptive immune system. Additionally, ABCB9 forms a homodimer and localizes in lysosomes, where ABCB9 operates as an ATP-dependent peptide transporter with broad specificity for peptides ranging from 6 to 59 amino acids in length. Despite exhibiting low affinity for substrates, ABCB9 demonstrates high transport efficiency, underscoring ABCB9′s significance in cellular peptide processing and immune surveillance.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ABCB9 Antibody (A-8) References:
- Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes. | Zhang, F., et al. 2000. J Biol Chem. 275: 23287-94. PMID: 10748049
- A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. | Kobayashi, A., et al. 2000. J Biochem. 128: 711-8. PMID: 11011155
- Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity. | Kobayashi, A., et al. 2003. Biochem Biophys Res Commun. 309: 815-22. PMID: 13679046
- The carboxyl terminal sequence of rat transporter associated with antigen processing (TAP)-like (ABCB9) is heterogeneous due to splicing of its mRNA. | Yamaguchi, Y., et al. 2004. Biol Pharm Bull. 27: 100-4. PMID: 14709908
- Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique. | Kobayashi, A., et al. 2004. Biol Pharm Bull. 27: 1916-22. PMID: 15577206
- Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9). | Wolters, JC., et al. 2005. J Biol Chem. 280: 23631-6. PMID: 15863492
- TAP and TAP-like--brothers in arms? | Zhao, C., et al. 2006. Naunyn Schmiedebergs Arch Pharmacol. 372: 444-50. PMID: 16525794
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABCB9 Antibody (A-8) | sc-393412 | 200 µg/ml | $316.00 | |||
ABCB9 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-527685 | 200 µg Ab; 10 µg BP | $354.00 | |||
ABCB9 Antibody (A-8): m-IgG1 BP-HRP Bundle | sc-533058 | 200 µg Ab; 20 µg BP | $354.00 | |||
ABCB9 Antibody (A-8) AC | sc-393412 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ABCB9 Antibody (A-8) HRP | sc-393412 HRP | 200 µg/ml | $316.00 | |||
ABCB9 Antibody (A-8) FITC | sc-393412 FITC | 200 µg/ml | $330.00 | |||
ABCB9 Antibody (A-8) PE | sc-393412 PE | 200 µg/ml | $343.00 | |||
ABCB9 Antibody (A-8) Alexa Fluor® 488 | sc-393412 AF488 | 200 µg/ml | $357.00 | |||
ABCB9 Antibody (A-8) Alexa Fluor® 546 | sc-393412 AF546 | 200 µg/ml | $357.00 | |||
ABCB9 Antibody (A-8) Alexa Fluor® 594 | sc-393412 AF594 | 200 µg/ml | $357.00 | |||
ABCB9 Antibody (A-8) Alexa Fluor® 647 | sc-393412 AF647 | 200 µg/ml | $357.00 | |||
ABCB9 Antibody (A-8) Alexa Fluor® 680 | sc-393412 AF680 | 200 µg/ml | $357.00 | |||
ABCB9 Antibody (A-8) Alexa Fluor® 790 | sc-393412 AF790 | 200 µg/ml | $357.00 |