ABC1 Antibody (AC10): sc-53482
- ABC1 Antibody (AC10) is a mouse monoclonal IgG1 κ, cited in 9 publications, provided at 200 µg/ml
- raised against amino acids 1874-2261 mapping near the C-terminus of ABC1 of human origin
- Anti-ABC1 Antibody (AC10) is recommended for detection of ABC1 of mouse, rat and human origin by WB, IP and IF
- Anti-ABC1 Antibody (AC10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ABC1 Antibody (AC10) for WB applications. These reagents are now offered in bundles with ABC1 Antibody (AC10) (see ordering information below).
ABC1 Antibody (AC10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ABC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-ABC1 antibody (AC10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ABC1, or ATP-binding cassette transporter 1, plays a crucial role in lipid metabolism by facilitating the transport of cholesterol and phospholipids across cellular membranes, which is vital for maintaining cellular homeostasis and preventing the accumulation of toxic lipids. ABC1 protein is predominantly located in the plasma membrane of cells, particularly in macrophages, where ABC1 is essential for the efflux of cholesterol to high-density lipoprotein particles, thereby influencing cholesterol levels in the bloodstream. Mutations in the ABC1 gene are associated with Tangier disease, a condition characterized by severely low levels of high-density lipoprotein and increased risk of cardiovascular disease. ABC1 is widely expressed across various human tissues, with particularly high levels found in the liver, lung, adrenal glands, placenta, and fetal tissue, and ABC1 expression is notably induced during monocyte differentiation and upregulated in the presence of acetylated low-density lipoprotein. ABC1 (AC10) monoclonal antibody is an invaluable tool for researchers studying lipid metabolism, cardiovascular health, and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ABC1 Antibody (AC10) References:
- ABC1: the gene for Tangier disease and beyond. | Ordovas, JM. 2000. Nutr Rev. 58: 76-9. PMID: 10812922
- ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. | Hamon, Y., et al. 2000. Nat Cell Biol. 2: 399-406. PMID: 10878804
- Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues. | Lawn, RM., et al. 2001. Arterioscler Thromb Vasc Biol. 21: 378-85. PMID: 11231917
- The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility. | Selva, DM., et al. 2004. J Lipid Res. 45: 1040-50. PMID: 15026428
- The polymorphism of the ATP-binding cassette transporter 1 gene modulates Alzheimer disease risk in Chinese Han ethnic population. | Sun, YM., et al. 2012. Am J Geriatr Psychiatry. 20: 603-11. PMID: 22377775
- ATP-binding cassette transporter 1 C69T and V825I polymorphisms in the development of atherosclerosis: a meta-analysis of 18,320 subjects. | Yin, YW., et al. 2015. Thromb Res. 135: 130-6. PMID: 25527331
- Expression of miRNAs Targeting ATP Binding Cassette Transporter 1 (ABCA1) among Patients with Significant Carotid Artery Stenosis. | Jeong, S., et al. 2021. Biomedicines. 9: PMID: 34440128
- Isoform- and cell-state-specific lipidation of ApoE in astrocytes. | Lindner, K., et al. 2022. Cell Rep. 38: 110435. PMID: 35235798
- PGC-1α promotes colorectal carcinoma metastasis through regulating ABCA1 transcription. | Chen, W., et al. 2023. Oncogene. 42: 2456-2470. PMID: 37400530
- ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes. | Becq, F., et al. 1997. J Biol Chem. 272: 2695-9. PMID: 9006906
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABC1 Antibody (AC10) | sc-53482 | 200 µg/ml | $322.00 | |||
ABC1 Antibody (AC10): m-IgG Fc BP-HRP Bundle | sc-526816 | 200 µg Ab; 10 µg BP | $361.00 | |||
ABC1 Antibody (AC10): m-IgG1 BP-HRP Bundle | sc-532189 | 200 µg Ab; 20 µg BP | $361.00 | |||
ABC1 Antibody (AC10) AC | sc-53482 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ABC1 Antibody (AC10) HRP | sc-53482 HRP | 200 µg/ml | $322.00 | |||
ABC1 Antibody (AC10) FITC | sc-53482 FITC | 200 µg/ml | $336.00 | |||
ABC1 Antibody (AC10) PE | sc-53482 PE | 200 µg/ml | $349.00 | |||
ABC1 Antibody (AC10) Alexa Fluor® 488 | sc-53482 AF488 | 200 µg/ml | $364.00 | |||
ABC1 Antibody (AC10) Alexa Fluor® 546 | sc-53482 AF546 | 200 µg/ml | $364.00 | |||
ABC1 Antibody (AC10) Alexa Fluor® 594 | sc-53482 AF594 | 200 µg/ml | $364.00 | |||
ABC1 Antibody (AC10) Alexa Fluor® 647 | sc-53482 AF647 | 200 µg/ml | $364.00 | |||
ABC1 Antibody (AC10) Alexa Fluor® 680 | sc-53482 AF680 | 200 µg/ml | $364.00 | |||
ABC1 Antibody (AC10) Alexa Fluor® 790 | sc-53482 AF790 | 200 µg/ml | $364.00 |