A-Raf Antibody (1): sc-135820
- A-Raf Antibody (1) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/500 µl
- raised against amino acids 183-199 of A-Raf of mouse origin
- recommended for detection of A-Raf of mouse, rat, human and canine origin by WB, IP and IF; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for A-Raf Antibody (1). This work is in progress.
A-Raf Antibody (1) is a mouse monoclonal IgG1 antibody that detects A-Raf in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). A-Raf is a crucial member of the Raf gene family of serine/threonine protein kinases, playing a significant role in regulating cell signaling pathways that control cell growth and differentiation. A-Raf expression is predominantly found in urogenital tissues and kidney, with lower levels in brain, highlighting A-Raf′s importance in tissue-specific signaling mechanisms. A-Raf′s structure includes a kinase domain sharing substantial homology with Raf-1, which is essential for enzymatic activity; however, regulatory elements outside this domain differ, suggesting unique regulatory mechanisms. Understanding A-Raf function and regulation is vital, as dysregulation can lead to various pathologies, including cancer, making A-Raf a significant target for therapeutic intervention. Anti-A-Raf antibody (1) provides a reliable tool for researchers investigating A-Raf′s role in cellular processes and disease implications.
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A-Raf Antibody (1) References:
- A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression. | Mercer, K., et al. 2005. Oncogene. 24: 5207-17. PMID: 15856007
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. | Bollag, G., et al. 2010. Nature. 467: 596-9. PMID: 20823850
- Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation. | Rauch, J., et al. 2016. Cell Death Differ. 23: 1283-95. PMID: 26891695
- A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation. | Zhang, Q., et al. 2016. Biochem Biophys Res Commun. 476: 438-444. PMID: 27240957
- A Raf-like protein kinase BHP mediates blue light-dependent stomatal opening. | Hayashi, M., et al. 2017. Sci Rep. 7: 45586. PMID: 28358053
- A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. | Kauke, MJ., et al. 2018. Mol Cancer Ther. 17: 1773-1780. PMID: 29720559
- A serine-rich effector from the stripe rust pathogen targets a Raf-like kinase to suppress host immunity. | Wan, C., et al. 2022. Plant Physiol. 190: 762-778. PMID: 35567492
- TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway. | Biswas, PK., et al. 2022. Int J Mol Sci. 23: PMID: 36142409
- PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling. | Wu, C., et al. 2023. Virol Sin. 38: 276-284. PMID: 36669700
- Phosphoproteomic analysis reveals changes in A-Raf-related protein phosphorylation in response to Toxoplasma gondii infection in porcine macrophages. | Su, D., et al. 2024. Parasit Vectors. 17: 191. PMID: 38643189
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-Raf Antibody (1) | sc-135820 | 50 µg/500 µl | $322.00 |