A-Myb Antibody (D-12): sc-514682
- A-Myb Antibody (D-12) is a mouse monoclonal IgM κ A-Myb antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 58-75 near the N-terminus of A-Myb of human origin
- recommended for detection of A-Myb of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for A-Myb Antibody (D-12). This work is in progress.
A-Myb Antibody (D-12) is a mouse monoclonal IgM antibody that detects A-Myb protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). A-Myb (D-12) antibody is available as the non-conjugated form. A-Myb protein, a member of the Myb family of transcription factors, plays a crucial role in regulating gene expression related to cellular differentiation and growth. A-Myb protein is characterized by a helix-turn-helix (HTH) DNA-binding domain, which allows binding to specific promoter sequences, thereby influencing target gene transcription. A-Myb protein regulation is particularly important in various biological processes, including hematopoiesis and reproductive tissue development. A-Myb protein is expressed at specific times in reproductive tissues and certain neural cells, as well as in a subset of normal and neoplastic B lymphocytes. A-Myb protein expression is implicated in t(14:18) lymphoma cells, where A-Myb protein inhibits cell cycle arrest and apoptotic signaling, highlighting potential roles in cancer biology. A-Myb protein activates the bcl-2 promoter, leading to increased Bcl-2 expression, which serves as an anti-apoptotic factor, promoting cell survival in conditions that typically induce apoptosis.
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A-Myb Antibody (D-12) References:
- The myb gene family in cell growth, differentiation and apoptosis. | Oh, IH. and Reddy, EP. 1999. Oncogene. 18: 3017-33. PMID: 10378697
- A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells. | Heckman, CA., et al. 2000. J Biol Chem. 275: 6499-508. PMID: 10692454
- Growth regulated expression of B-myb in fibroblasts and hematopoietic cells. | Reiss, K., et al. 1991. J Cell Physiol. 148: 338-43. PMID: 1717494
- DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB. | Mizuguchi, G., et al. 1990. J Biol Chem. 265: 9280-4. PMID: 2160970
- Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. | Sakura, H., et al. 1989. Proc Natl Acad Sci U S A. 86: 5758-62. PMID: 2668947
- The carboxyterminus of human c-myb protein stimulates activated transcription in trans. | Vorbrueggen, G., et al. 1994. Nucleic Acids Res. 22: 2466-75. PMID: 8041607
- The human A-myb protein is a strong activator of transcription. | Golay, J., et al. 1994. Oncogene. 9: 2469-79. PMID: 8058310
- Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. | Golay, J., et al. 1996. Blood. 87: 1900-11. PMID: 8634438
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-Myb Antibody (D-12) | sc-514682 | 200 µg/ml | $322.00 | |||
A-Myb (D-12) Neutralizing Peptide | sc-514682 P | 100 µg/0.5 ml | $69.00 |