Adenylate cyclase 10/ADCY10 Antibody (B-1): sc-515097

A cyclase X Antibody (B-1) is a mouse monoclonal IgM antibody that detects A cyclase X protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-A cyclase X antibody (B-1) is available as the non-conjugated form. A cyclase X protein, also known as ADCY10, is a soluble adenylyl cyclase consisting of 1,610 amino acids and plays a crucial role in converting ATP to cyclic AMP (cAMP), a vital second messenger involved in numerous physiological processes. cAMP is essential for mediating the effects of various hormones and neurotransmitters, influencing key cellular functions such as metabolism, gene transcription, and memory formation. Notably, A cyclase X acts as a bicarbonate sensor, which is particularly important in regulating spermatogenesis, highlighting its significance in reproductive health. A cyclase X exists in three alternatively spliced isoforms that localize to both the cytoplasm and cell membrane, allowing for versatile signaling capabilities in response to receptor-initiated signals mediated by Gs and Gi heterotrimeric G proteins. A cyclase X′s ability to respond to these signals underscores its importance in maintaining cellular homeostasis and facilitating communication within and between cells.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Adenylate cyclase 10/ADCY10 Antibody (B-1) References:

1. Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24.  |  Reed, BY., et al. 1999. J Clin Endocrinol Metab. 84: 3907-13. PMID: 10566627
2. Specific expression of soluble adenylyl cyclase in male germ cells.  |  Sinclair, ML., et al. 2000. Mol Reprod Dev. 56: 6-11. PMID: 10737962
3. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.  |  Chen, Y., et al. 2000. Science. 289: 625-8. PMID: 10915626
4. Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density.  |  Reed, BY., et al. 2002. J Clin Endocrinol Metab. 87: 1476-85. PMID: 11932268
5. The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.  |  Hess, KC., et al. 2005. Dev Cell. 9: 249-59. PMID: 16054031
6. Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults.  |  Ichikawa, S., et al. 2009. Calcif Tissue Int. 84: 97-102. PMID: 19093065
7. Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.  |  Zippin, JH., et al. 2010. J Invest Dermatol. 130: 1279-87. PMID: 20130594
8. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals.  |  Buck, J., et al. 1999. Proc Natl Acad Sci U S A. 96: 79-84. PMID: 9874775

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenylate cyclase 10/ADCY10 Antibody (B-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenylate cyclase 10/ADCY10 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenylate cyclase 10/ADCY10 Antibody (B-1) Specifications

Alternate Product Name: A cyclase X

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1328-1346

Epitope Target: A cyclase X

Epitope Species: human

Product Reactivity/Detection: A cyclase X

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Adenylate cyclase 10/ADCY10 Antibody (B-1): P: Blocking Peptide