Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6): sc-377323

A cyclase VIII Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects A cyclase VIII protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-A cyclase VIII antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. A cyclase VIII (B-6) antibody enables research into ATP to cyclic AMP conversion, a vital second messenger involved in numerous signaling pathways regulating physiological processes such as metabolism, cell growth, and neuronal signaling. A cyclase VIII (B-6) monoclonal antibody supports studies in the central nervous system, where A cyclase VIII is one of three calcium-stimulated isoforms expressed in a region-specific manner, highlighting potential roles in modulating synaptic plasticity and cognitive functions. Anti-A cyclase VIII antibody (B-6) aids research into various neurological conditions, including alcoholism and Alzheimer′s disease, where A cyclase VIII dysregulation may contribute to impaired learning and memory. A cyclase VIII (B-6) monoclonal antibody facilitates studies showing that A cyclase VIII knock-out mice exhibit abnormal anxiety-related behavioral responses. A cyclase VIII (B-6) antibody serves as an essential tool for investigating cyclic AMP signaling in health and disease.

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Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6) References:

1. The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice.  |  Muglia, LM., et al. 1999. J Neurosci. 19: 2051-8. PMID: 10066258
2. Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.  |  Schaefer, ML., et al. 2000. J Neurosci. 20: 4809-20. PMID: 10864938
3. Hippocampal level of neural specific adenylyl cyclase type I is decreased in Alzheimer's disease.  |  Yamamoto, M., et al. 2000. Biochim Biophys Acta. 1535: 60-8. PMID: 11113632
4. Increased levels of calcium-sensitive adenylyl cyclase subtypes in the limbic system of alcoholics: evidence for a specific role of cAMP signaling in the human addictive brain.  |  Yamamoto, M., et al. 2001. Brain Res. 895: 233-7. PMID: 11259782
5. Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB.  |  Chao, JR., et al. 2002. Eur J Neurosci. 16: 1284-94. PMID: 12405989
6. Adenylyl cyclases.  |  Tang, WJ. and Gilman, AG. 1992. Cell. 70: 869-72. PMID: 1525824
7. Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation.  |  Steiner, D., et al. 2005. Biochem J. 386: 341-8. PMID: 15537392
8. The GTPase superfamily: a conserved switch for diverse cell functions.  |  Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
9. G proteins: transducers of receptor-generated signals.  |  Gilman, AG. 1987. Annu Rev Biochem. 56: 615-49. PMID: 3113327
10. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.  |  Taussig, R., et al. 1994. J Biol Chem. 269: 6093-100. PMID: 8119955
11. Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.  |  Cali, JJ., et al. 1994. J Biol Chem. 269: 12190-5. PMID: 8163524
12. Splice variants of type VIII adenylyl cyclase. Differences in glycosylation and regulation by Ca2+/calmodulin.  |  Cali, JJ., et al. 1996. J Biol Chem. 271: 1089-95. PMID: 8557635

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6) Specifications

Alternate Product Name: A cyclase VIII

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 561-830

Epitope Target: A cyclase VIII

Epitope Species: human

Product Reactivity/Detection: A cyclase VIII

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin