Adenylate cyclase 5/6/ADCY5/ADCY6 Antibody (B-6): sc-514785

A cyclase V/VI Antibody (B-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects A cyclase V/VI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-A cyclase V/VI antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. A cyclase V/VI (B-6) antibody recognizes a protein that plays a crucial role in cellular signaling by converting ATP to cyclic AMP, a second messenger that mediates the effects of numerous hormones and neurotransmitters. This conversion is vital for regulating diverse physiological processes, including metabolism, gene expression, and neuronal signaling, which are essential for maintaining homeostasis and responding to environmental changes. A cyclase V/VI (B-6) monoclonal antibody targets enzymes that are intricately regulated by G protein-coupled receptors, where the binding of an agonist leads to activation and signal amplification. AC V and AC VI are predominantly expressed in the heart, with AC V also found in lower levels in the brain, highlighting their importance in cardiovascular function and potential implications in neurological processes. A cyclase V/VI (B-6) monoclonal antibody serves as an invaluable tool for researchers studying these pathways and their role in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Adenylate cyclase 5/6/ADCY5/ADCY6 Antibody (B-6) References:

1. PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle.  |  Murthy, KS., et al. 2002. Am J Physiol Cell Physiol. 282: C508-17. PMID: 11832336
2. Expression of adenylyl cyclase V/VI mRNA and protein is upregulated in cyanotic infant human myocardium.  |  Zhao, Y., et al. 2002. Pediatr Cardiol. 23: 536-41. PMID: 12189409
3. Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.  |  Premont, RT., et al. 1992. Proc Natl Acad Sci U S A. 89: 9809-13. PMID: 1409703
4. Adenylyl cyclases.  |  Tang, WJ. and Gilman, AG. 1992. Cell. 70: 869-72. PMID: 1525824
5. Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.  |  Katsushika, S., et al. 1992. Proc Natl Acad Sci U S A. 89: 8774-8. PMID: 1528892
6. Identification of a dysfunctional missense single nucleotide variant of human adenylyl cyclase VI.  |  Gros, R., et al. 2005. Clin Pharmacol Ther. 77: 271-8. PMID: 15903125
7. Isolation and characterization of a novel cardiac adenylylcyclase cDNA.  |  Ishikawa, Y., et al. 1992. J Biol Chem. 267: 13553-7. PMID: 1618857
8. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.  |  Bauman, AL., et al. 2006. Mol Cell. 23: 925-31. PMID: 16973443
9. The GTPase superfamily: a conserved switch for diverse cell functions.  |  Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
10. G proteins: transducers of receptor-generated signals.  |  Gilman, AG. 1987. Annu Rev Biochem. 56: 615-49. PMID: 3113327
11. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.  |  Taussig, R., et al. 1994. J Biol Chem. 269: 6093-100. PMID: 8119955
12. Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors.  |  Nevo, I., et al. 1998. Mol Pharmacol. 54: 419-26. PMID: 9687584

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenylate cyclase 5/6/ADCY5/ADCY6 Antibody (B-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenylate cyclase 5/6/ADCY5/ADCY6 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenylate cyclase 5/6/ADCY5/ADCY6 Antibody (B-6) Specifications

Alternate Product Name: Adenylate Cyclase 1/5/6

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1144-1165

Epitope Target: A cyclase VI

Epitope Species: human

Product Reactivity/Detection: A cyclase V and A cyclase VI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Adenylate cyclase 5/6/ADCY5/ADCY6 Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin