Adenylate cyclase 2/AC2/ADCY2 Antibody (F-7): sc-514938

A cyclase II Antibody (F-7) is a mouse monoclonal IgM antibody that detects A cyclase II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-A cyclase II antibody (F-7) is available as the non-conjugated form. A cyclase II (F-7) antibody recognizes a protein that plays a crucial role in cellular signaling by converting ATP to cyclic AMP, a secondary messenger mediating various physiological responses, including metabolism, gene transcription, and memory formation. This conversion activates a range of downstream targets, influencing numerous biological processes. A cyclase II regulation is intricately linked to receptor-initiated signals mediated by Gs and Gi heterotrimeric G proteins. Binding of an agonist to a Gs-coupled receptor triggers a cascade leading to A cyclase II activation, highlighting its importance in modulating cellular responses to external stimuli. A cyclase II is conditionally stimulated by Gα s/βγ subunits and regulated through protein kinase C-mediated phosphorylation, adding another layer of complexity to its function. A cyclase II (F-7) monoclonal antibody helps researchers understand protein dynamics and interactions essential for elucidating mechanisms underlying various physiological and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Adenylate cyclase 2/AC2/ADCY2 Antibody (F-7) References:

1. Heterologous sensitization of recombinant adenylate cyclases by activation of D(2) dopamine receptors.  |  Cumbay, MG. and Watts, VJ. 2001. J Pharmacol Exp Ther. 297: 1201-9. PMID: 11356947
2. Adenylyl cyclases.  |  Tang, WJ. and Gilman, AG. 1992. Cell. 70: 869-72. PMID: 1525824
3. The GTPase superfamily: a conserved switch for diverse cell functions.  |  Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
4. G proteins: transducers of receptor-generated signals.  |  Gilman, AG. 1987. Annu Rev Biochem. 56: 615-49. PMID: 3113327
5. Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.  |  Jacobowitz, O. and Iyengar, R. 1994. Proc Natl Acad Sci U S A. 91: 10630-4. PMID: 7938004
6. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.  |  Taussig, R., et al. 1994. J Biol Chem. 269: 6093-100. PMID: 8119955
7. Adenylyl cyclase type II is stimulated by PKC via C-terminal phosphorylation.  |  Böl, GF., et al. 1997. Biochim Biophys Acta. 1358: 307-13. PMID: 9366262

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenylate cyclase 2/AC2/ADCY2 Antibody (F-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenylate cyclase 2/AC2/ADCY2 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenylate cyclase 2/AC2/ADCY2 Antibody (F-7) Specifications

Alternate Product Name: A cyclase II

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 777-802

Epitope Target: A cyclase II

Epitope Species: human

Product Reactivity/Detection: A cyclase II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Adenylate cyclase 2/AC2/ADCY2 Antibody (F-7): P: Blocking Peptide