Adenylate cyclase 1/AC1/ADCY1 Antibody (F-10): sc-365350

A cyclase I Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects A cyclase I protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-A cyclase I antibody (F-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. A cyclase I, also known as AC1 or ADCY1, is a critical multi-pass membrane protein consisting of 1,119 amino acids, predominantly expressed in the brain, retina, and adrenal medulla. A cyclase I catalyzes the conversion of ATP to cyclic AMP in response to hormonal and neurotransmitter signals, which is essential for regulating numerous physiological processes, including metabolism, gene transcription, and memory formation. Cyclic AMP as a second messenger activates various downstream targets that mediate these diverse biological effects. A cyclase I binds two magnesium ions per subunit, which is crucial for enzymatic activity and regulatory functions within the central nervous system. A cyclase I responds to receptor-initiated signals, particularly those mediated by Gs and Gi heterotrimeric G proteins, underscoring A cyclase I (F-10) monoclonal antibody′s value for researchers studying these complex mechanisms.

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Adenylate cyclase 1/AC1/ADCY1 Antibody (F-10) References:

1. FlCRhR/cyclic AMP signaling in myenteric ganglia and calbindin-D28 intrinsic primary afferent neurons involves adenylyl cyclases I, III and IV.  |  Liu, CY., et al. 1999. Brain Res. 826: 253-69. PMID: 10224303
2. Ca(2+), Sr(2+), and Ba(2+) identify distinct regulatory sites on adenylyl cyclase (AC) types VI and VIII and consolidate the apposition of capacitative cation entry channels and Ca(2+)-sensitive ACs.  |  Gu, C. and Cooper, DM. 2000. J Biol Chem. 275: 6980-6. PMID: 10702261
3. A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones.  |  Parkinson, NA. and Bolsover, SR. 2001. Brain Res Mol Brain Res. 91: 43-9. PMID: 11457491
4. Protein associated with Myc (PAM) is a potent inhibitor of adenylyl cyclases.  |  Scholich, K., et al. 2001. J Biol Chem. 276: 47583-9. PMID: 11590159
5. Adenylyl cyclases.  |  Tang, WJ. and Gilman, AG. 1992. Cell. 70: 869-72. PMID: 1525824
6. The GTPase superfamily: a conserved switch for diverse cell functions.  |  Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
7. Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.  |  Suzuki, A., et al. 2015. Neuroscience. 290: 518-29. PMID: 25644422
8. G proteins: transducers of receptor-generated signals.  |  Gilman, AG. 1987. Annu Rev Biochem. 56: 615-49. PMID: 3113327
9. A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance.  |  Giacoletti, G., et al. 2022. Front Pharmacol. 13: 935588. PMID: 35899113
10. Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate.  |  Bose, SJ., et al. 2022. Front Pharmacol. 13: 951897. PMID: 36105228
11. Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice.  |  Johnson, K., et al. 2022. Front Pharmacol. 13: 937741. PMID: 36120355
12. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.  |  Taussig, R., et al. 1994. J Biol Chem. 269: 6093-100. PMID: 8119955

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenylate cyclase 1/AC1/ADCY1 Antibody (F-10) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenylate cyclase 1/AC1/ADCY1 Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenylate cyclase 1/AC1/ADCY1 Antibody (F-10) Specifications

Alternate Product Name: A cyclase I

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1085-1119

Epitope Target: A cyclase I

Epitope Species: human

Product Reactivity/Detection: A cyclase I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Adenylate cyclase 1/AC1/ADCY1 Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin