4E-T Antibody (2314C3a): sc-81175
- 4E-T Antibody (2314C3a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the N-terminus of 4E-T of human origin
- recommended for detection of 4E-T of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 4E-T Antibody (2314C3a). This work is in progress.
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SEE ALSO...
4E-T Antibody (2314C3a) is a mouse monoclonal IgG1 antibody that detects eIF4E-Transporter (4E-T) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). 4E-T plays a crucial role in protein synthesis regulation by facilitating eIF4E nuclear import, a key component of the eukaryotic initiation complex eIF4F essential for ribosome binding to mRNA. The interaction between 4E-T and eIF4E occurs through a conserved binding site, highlighting 4E-T′s importance in translation initiation. 4E-T contains a bipartite nuclear localization signal and two leucine-rich nuclear export signals, vital for nucleocytoplasmic transport function. The 4E-T gene is located on human chromosome 22q11.2, and understanding 4E-T function and interactions helps elucidate gene expression regulation mechanisms and potential implications in various diseases, including cancer, where protein synthesis dysregulation is often observed.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4E-T Antibody (2314C3a) | sc-81175 | 100 µg/ml | $339.00 |