4.1R Antibody (A-4): sc-398983

4.1R Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects 4.1R in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4.1R is a crucial multifunctional protein that plays a significant role in maintaining the shape and mechanical properties of erythrocyte membranes, which is vital for proper red blood cell function and overall circulatory health. 4.1R is part of the 4.1 gene family, which includes other members like 4.1G, 4.1N, and 4.1B, and is predominantly expressed in the nervous system and red blood cells. The unique distribution of 4.1R in the cerebellum suggests involvement in modulating the mechanical properties of neuronal cell membranes, thereby influencing neuronal signaling and stability. Additionally, 4.1R interacts with spectrin and actin, forming a critical cytoskeletal network that supports cell shape and integrity. The importance of 4.1R is underscored by association with hereditary elliptocytosis, a condition that affects red blood cell morphology and can lead to hemolytic anemia. With an ability to detect multiple forms of 4.1R enriched in specific cellular contexts, anti-4.1R antibody (A-4) serves as an invaluable tool for researchers studying erythrocyte biology and related neurological functions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

4.1R Antibody (A-4) References:

1. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation.  |  Kontrogianni-Konstantopoulos, A., et al. 2001. J Biol Chem. 276: 20679-87. PMID: 11274145
2. Cardiac cytoskeleton and arrhythmia: an unexpected role for protein 4.1R in cardiac excitability.  |  Cunha, SR. and Mohler, PJ. 2008. Circ Res. 103: 779-81. PMID: 18845816
3. Protein 4.1R is Involved in the Transport of 5-Aminolevulinic Acid by Interaction with GATs in MEF Cells.  |  Ning, S., et al. 2018. Photochem Photobiol. 94: 173-178. PMID: 28881432
4. Protein 4.1R negatively regulates CD8+ T-cell activation by modulating phosphorylation of linker for activation of T cells.  |  Fan, D., et al. 2019. Immunology. 157: 312-321. PMID: 31135971
5. Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.  |  Huang, SC., et al. 2020. J Biol Chem. 295: 191-211. PMID: 31776189
6. Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.  |  Draberova, L., et al. 2019. Front Immunol. 10: 3068. PMID: 31993060
7. Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.  |  Huang, SC., et al. 2021. J Biol Chem. 297: 101051. PMID: 34364872
8. Cell membrane skeletal protein 4.1R participates in entry of Zika virus into cells.  |  Su, S., et al. 2021. Virus Res. 306: 198593. PMID: 34637814
9. The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.  |  Lu, Y., et al. 2021. Exp Cell Res. 409: 112896. PMID: 34717920
10. PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis.  |  Okujima, Y., et al. 2024. Sci Rep. 14: 27768. PMID: 39532917

The preferred 4.1R antibody is 4.1R Antibody (B-11): sc-166759.