4.1B Antibody (485): sc-100641
- 4.1B Antibody (485) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant 4.1B of human origin
- recommended for detection of 4.1B of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 4.1B Antibody (485). This work is in progress.
4.1B Antibody (485) is a mouse monoclonal IgG2a antibody that detects 4.1B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). 4.1B, also known as EPB41L3, is a member of the 4.1 gene family, which encodes a group of multifunctional cytoskeletal proteins that play critical roles in maintaining cell shape and mechanical properties. 4.1B is predominantly expressed in the brain and is particularly important for its involvement in the stabilization of the spectrin-actin cytoskeleton, which is essential for the structural integrity of neuronal cells. The unique distribution of 4.1B in the cerebellum suggests that 4.1B may modulate the mechanical properties of neuronal membranes, thereby influencing synaptic function and plasticity. Additionally, 4.1B interacts with other proteins in the postsynaptic density, contributing to the complex signaling networks that are vital for neurotransmission. Anti-4.1B antibody (485) detects multiple forms of 4.1B, enhancing research utility in studies focused on neuronal function and pathology, making anti-4.1B antibody (485) an invaluable tool for scientists studying the intricate dynamics of the nervous system.
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4.1B Antibody (485) References:
- Potential role of EPB41L3 (protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer. | Bernkopf, DB. and Williams, ED. 2008. Expert Opin Ther Targets. 12: 845-53. PMID: 18554153
- Protein 4.1B contributes to the organization of peripheral myelinated axons. | Cifuentes-Diaz, C., et al. 2011. PLoS One. 6: e25043. PMID: 21966409
- The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons. | Einheber, S., et al. 2013. Glia. 61: 240-53. PMID: 23109359
- Tumor suppressor role of protein 4.1B/DAL-1. | Wang, Z., et al. 2014. Cell Mol Life Sci. 71: 4815-30. PMID: 25183197
- DAL-1/4.1B contributes to epithelial-mesenchymal transition via regulation of transforming growth factor-β in lung cancer cell lines. | Yu, F., et al. 2015. Mol Med Rep. 12: 6072-8. PMID: 26300315
- Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells. | Wang, Z., et al. 2017. Mol Carcinog. 56: 538-549. PMID: 27312663
- Protein 4.1B Suppresses Tumor Metastasis by Regulating Epithelial-mesenchymal Transition Progression in Melanoma Cells. | Wang, C., et al. 2019. Int J Med Sci. 16: 529-536. PMID: 31171904
- 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment. | Xue, F., et al. 2019. Cell Commun Signal. 17: 115. PMID: 31492173
- Correlation between protein 4.1a/4.1b ratio and erythrocyte life span. | Inaba, M. and Maede, Y. 1988. Biochim Biophys Acta. 944: 256-64. PMID: 3179290
- DAL-1/4.1B promotes the uptake of exosomes in lung cancer cells via Heparan Sulfate Proteoglycan 2 (HSPG2). | Zhang, S., et al. 2022. Mol Cell Biochem. 477: 241-254. PMID: 34657240
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4.1B Antibody (485) | sc-100641 | 100 µg/ml | $339.00 |