Molecular structure of 3-Bromocytisine, CAS Number: 207390-14-5
3-Bromocytisine (CAS 207390-14-5)
Application:
3-Bromocytisine is a potent AChR agonist
CAS Number:
207390-14-5
Molecular Weight:
269.14
Molecular Formula:
C11H13BrN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Bromocytisine is a potent nAch receptor agonist of α4β4, α4β2 and α7 nACh receptors. The compound has been documented to display differing effects on high and low ACh sensitivity α4β2 nAChRs with respective recorded EC50 values of 0.008 and 0.05 μM.
3-Bromocytisine (CAS 207390-14-5) References
- Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors. | Houlihan, LM., et al. 2001. J Neurochem. 78: 1029-43. PMID: 11553677
- Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: effects of cytisine and its bromo derivatives. | Varas, R., et al. 2006. Brain Res. 1072: 72-8. PMID: 16406013
- C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists. | Abin-Carriquiry, JA., et al. 2006. Eur J Pharmacol. 536: 1-11. PMID: 16563372
- alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. | Moroni, M., et al. 2006. Mol Pharmacol. 70: 755-68. PMID: 16720757
- In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's Disease. | Abin-Carriquiry, JA., et al. 2008. Eur J Pharmacol. 589: 80-4. PMID: 18589414
- Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats. | Abin-Carriquiry, JA., et al. 2010. Eur J Pharmacol. 634: 89-94. PMID: 20184877
- Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. | Kiss, T., et al. 2014. PLoS One. 9: e109538. PMID: 25303328
- Pharmacological profile of Ascaris suum ACR-16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissues. | Abongwa, M., et al. 2016. Br J Pharmacol. 173: 2463-77. PMID: 27238203
- Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16. | Choudhary, S., et al. 2019. Invert Neurosci. 19: 11. PMID: 31486912
- Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine. | Quintanilla, ME., et al. 2023. Drug Alcohol Depend. 250: 110900. PMID: 37515828
Inhibitor of:
CHRNB4.Activator of:
AChR α 4, AChR α 7, and AChRbeta2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Bromocytisine, 10 mg | sc-361077 | 10 mg | $179.00 | |||
3-Bromocytisine, 50 mg | sc-361077A | 50 mg | $760.00 |