3-Bromocytisine CAS: 207390-14-5
MF: C11H13BrN2O
MW: 269.14
A potent AChR agonist.

3-Bromocytisine (CAS 207390-14-5)

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Application: 3-Bromocytisine is a potent AChR agonist
CAS Number: 207390-14-5
Molecular Weight: 269.14
Molecular Formula: C11H13BrN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

3-Bromocytisine is a potent AChR agonist of α4β4, α4β2 and α7 AChR. The compound has been documented to display differing effects on high and low acetylcholine sensitivity AChR α4β2 with respective recorded EC50 values of 0.008 and 0.05 µM.


References

1. Houlihan, L.M., et al. 2001. J. Neurochem. 78: 1029-1043. PMID: 11553677
2. Moroni, M., et al. 2006. Mol. Pharmacol. 70: 755-768. PMID: 16720757

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
155.54° C (Predicted)
Boiling Point :
~463.3° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
AChRα4β4: IC50 = 0.28 nM; AChRα4β2: IC50 = 0.30 nM; AChRα3β4: IC50 = 15.6 nM (human); AChRα3: IC50 = 15.6 nM (human); AChRα7: IC50 = 31.6 nM
Ki Data :
Neuronal acetylcholine receptor; α4/β2: Ki= 0.12 nM (rat); Neuronal acetylcholine receptor protein α-7 subunit: Ki= 401.1 nM (rat)
pK Values :
pKb: 10.15 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
15519735
SMILES :
C1[[email protected]]2CNC[[email protected]@H]1C3=CC=C(C(=O)N3C2)Br

Download SDS (MSDS)

Certificate of Analysis

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